| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:SID 3712249
CAS:522606-67-3
Purity:大于98% Package:1g,5g,10g,25g根據(jù)客戶需要分裝 Remarks:Not For Human Use, Lab Use Only.
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SID 3712249 manufacturers
- SID 3712249
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- $48.00 / 2mg
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2024-10-24
- CAS:522606-67-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | SID 3712249 Basic information |
| Product Name: | SID 3712249 | | Synonyms: | SID 3712249;miR544-IN-1;1,8-diamino-3,6-di(1-pyrrolidinyl)[2,7]naphthyridine-4-carbonitrile;MiR-544 Inhibitor 1;2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl-;SID 3712249 >=95% (HPLC) | | CAS: | 522606-67-3 | | MF: | C17H21N7 | | MW: | 323.4 | | EINECS: | | | Product Categories: | | | Mol File: | 522606-67-3.mol |  |
| | SID 3712249 Chemical Properties |
| Boiling point | 669.0±55.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml | | form | A crystalline solid | | pka | 8.83±0.30(Predicted) | | color | Light yellow to yellow |
| | SID 3712249 Usage And Synthesis |
| Uses | SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer[1]. | | Biological Activity | SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2μ-O-methyl RNA antagomir. | | in vivo | SID 3712249 (compound 1, 100 μL of 40 μM, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model[1].
SID 3712249 (20 nM, pre-treated GFP-labeled MDA-MB-231 cells, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model[1]. | Animal Model: | MDA-MB-231-GFP-luc tumor model[1] | | Dosage: | 100 μL of 40 μM | | Administration: | Intraperitoneal injection | | Result: | Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects.
Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).
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| | References | [1] Christopher L Haga, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76. DOI:10.1021/acschembio.5b00265 |
| | SID 3712249 Preparation Products And Raw materials |
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