15-Lipoxygenase Inhibitor 1
| 中文名稱 | 15-Lipoxygenase Inhibitor 1 |
|---|---|
| 中文同義詞 | 化合物15-LIPOXYGENASE INHIBITOR 1;4-甲基-2-(4-甲基哌嗪-1-基)-5H-苯并[B]嘧啶并[5,4-E][1,4]噻嗪;化合物15-LIPOXYGENASE INHIBITOR 1,10 MM DMSO 溶液;4-MMPB 試劑;4-MMPB 試劑 |
| 英文名稱 | 15-Lipoxygenase Inhibitor 1 |
| 英文同義詞 | 15-Lipoxygenase Inhibitor 1;15-Lipoxygenase Inhibitor I;15-Lipoxygenase Inhibitor 1 Exclusive;4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine;15-Lipoxygenase Inhibitor 1(4-MMPB);4-MMPB;15-Lipoxygenast Inhibitorl;LOX,4 MMPB,radical,Inhibitor,inhibit,4-MMPB,scavenging,Lipoxygenase,cancer,Apoptosis,4MMPB,inhibition |
| CAS號 | 928853-86-5 |
| 分子式 | C16H19N5S |
| 分子量 | 313.42 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 928853-86-5.mol |
| 結(jié)構(gòu)式 |  |
15-Lipoxygenase Inhibitor 1 性質(zhì)
| 沸點 | 532.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.265±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 氯仿：>5mg/ml |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 7.17±0.42(Predicted) |
| 顏色 | 淺黃至橙色 |
4-MMPB 是一種選擇性的脂氧合酶 15-lipoxygenase 抑制劑，其 IC50 值為 18 μM。4-MMPB 對大豆 15-脂氧合酶 (SLO) 和人 15-脂氧合酶-1 (15-LOX-1) 作用的 IC50 值分別為 19.5 μM 和 19.1 μM。4-MMPB 具有潛力用于前列腺癌的研究。
IC50: 18 μM (15-lipoxygenase)
4-MMPB has an IC
50
of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay
| Cell Line: | DU145 cells, PC-3 cells, HFF3 cells |
| Concentration: | 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM,159.53 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-118480 | 15-Lipoxygenase Inhibitor 1 4-MMPB | 928853-86-5 | 1 mg | 454元 |
| 2025/05/22 | HY-118480 | 15-Lipoxygenase Inhibitor 1 4-MMPB | 928853-86-5 | 10mM * 1mLin DMSO | 724元 |