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4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine

4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ILK-IN-3
CAS:6975-75-3
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:ILK-IN-3
CAS:6975-75-3
Purity:99.69% Package:1mg;30USD|5mg;64USD|10mg;106USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:QLT0267
CAS:6975-75-3
Purity:98% Package:2mg Remarks:V8005
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:ILK-IN-3
CAS:6975-75-3
Package:10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:ILK-IN-3
CAS:6975-75-3
Purity:99% Package:$220.9/5mg;$350.9/10mg;$630.9/25mg;$1000.9/50mg;Bulk package Remarks:99%

4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine manufacturers

  • ILK-IN-3
  • ILK-IN-3 pictures
  • $30.00 / 1mg
  • 2024-11-19
  • CAS:6975-75-3
  • Min. Order:
  • Purity: 99.69%
  • Supply Ability: 10g
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Basic information
Product Name:4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
Synonyms:3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine;4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine;ILK-IN-3;1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-;antitumor,Integrin,inhibit,ILK,Inhibitor,ILK IN 3,ILKIN3;ILK-IN-3, 10 mM in DMSO
CAS:6975-75-3
MF:C10H12N6O
MW:232.24
EINECS:
Product Categories:
Mol File:6975-75-3.mol
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Structure
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Chemical Properties
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: 83.33 mg/mL (358.81 mM)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Usage And Synthesis
Biological ActivityQLT0267 is an orally active, potent and selective integrin-linked kinase (ILK) inhibitor (IC50 = 26 nM; selectivity: >1000-fold over CK2, CSK, DNA-PK, PIM1, PKB/AKT, PKC, >100-fold over ERK1, GSK3β, LCK, PKA, p70S6K, and RSK1/QLT, >10-fold over CDK1/2/5) th at inhibits ILK-dependent cellular signaling (IC50 in 2h = 1 μM against 20 nM EGF-induced pAKT Ser473 phosphorylation in Hth74 cells). QLT0267 treatment causes thyroid cancer cell cycle arrest and apoptosis, leading to anti-proliferation efficacy in cultures (IC50 <6 μM; NPA187, DRO, and K4 cell lines) and in mice in vivo (DRO xenografts-derived tumor growth; 50-100 mg/kg via daily p.o.).
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Preparation Products And Raw materials
Raw materialsPropanedinitrile,2-[2-(4-methoxyphenyl)diazenyl]--->p-Anisidine
Tag:4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine(6975-75-3) Related Product Information