182073-77-4
| 中文名稱 | 182073-77-4 |
|---|---|
| 中文同義詞 | 化合物 T17288;化合物 ZD8321 |
| 英文名稱 | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE |
| 英文同義詞 | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE;ZD8321;L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-;ZD-8321,ZD8321 |
| CAS號 | 182073-77-4 |
| 分子式 | C18H28F3N3O5 |
| 分子量 | 423.43 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 182073-77-4.mol |
| 結(jié)構(gòu)式 |  |
182073-77-4 性質(zhì)
| 沸點 | 573.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 11.22±0.46(Predicted) |
| 顏色 | 淺黃至黃色 |
ZD8321 是人 Neutrophil elastase (NE) 的有效抑制劑，其 Ki 值為 13±1.7 nM。
Ki: 13±1.7 nM (Neutrophil elastase)
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.