SR 33805
| 中文名稱 | SR 33805 |
|---|---|
| 中文同義詞 | 化合物SR33805;3,4-二甲氧基-N-甲基-N-[3-[4-[[1-甲基-2-2-(1-甲基乙基))-1H-吲哚-‐3-基]磺?；鵠苯氧基]丙基]苯乙胺;化合物SR33805,10 MM DMSO 溶液 |
| 英文名稱 | SR 33805 |
| 英文同義詞 | SR 33805;Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805;2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[1-methyl-2-(propan-2-yl)-1H-indol-3-yl]sulfonyl}phenoxy)propyl]amine;SR33805, 10 mM in DMSO |
| CAS號(hào) | 121345-64-0 |
| 分子式 | C32H40N2O5S |
| 分子量 | 564.7354 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 121345-64-0.mol |
| 結(jié)構(gòu)式 |  |
SR 33805 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
|
L-type calcium channel 4.1 nM (EC 50 , in depolarized conditions) |
L-type calcium channel 33 nM (EC 50 , in polarized conditions) |
SR33805 (0.01-10 μM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20
SR33805 (10 μM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca
2+
transient amplitude.
SR33805 (10 μM) decreases the activity of recombinant PKA.
Cell Viability Assay
| Cell Line: | Smooth muscle cells (SMC) |
| Concentration: | 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 3 days |
| Result: | Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC 50 s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 μM, respectively. |
SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.
| Animal Model: | Male Wistar rats (5 weeks) are subjected to coronary artery ligature |
| Dosage: | 0.2, 2, 20 mg/kg |
| Administration: | A single i.p. injection |
| Result: |
Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.
Did not affect other contractile parameters. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-136909 | SR33805 | 121345-64-0 | 1 mg | 410元 |
| 2025/02/08 | HY-136909 | SR 33805 SR33805 | 121345-64-0 | 5mg | 1110元 |