| | 103300-74-9 Basic information More.. |
| Product Name: | Taltirelin | | Synonyms: | Taltirelin interMediate;(4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl-;Ceredist, TA-0910;TALTIRELIN INTERMEDIATES;Taltirelin Acetate,TA-0910;Taltirelin;L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)-;L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI) | | CAS: | 103300-74-9 | | MF: | C17H23N7O5 | | MW: | 405.41 | | EINECS: | | | Mol File: | 103300-74-9.mol |  |
Use
Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in
particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the
first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH)
analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide.
It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on
the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher
doses, taltirelin has been found to increase the extracellular levels of dopamine and its
metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline
and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in
the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed
in patients suffering from various forms of SCD, taltirelin demonstrated a statistically
significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.
- Taltirelin
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- US $0.00-0.00 / kg
- 2025-04-04
- CAS:103300-74-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- Taltirelin
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- US $120.00 / KG
- 2025-03-21
- CAS:103300-74-9
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 1T
- Taltirelin
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- US $59.00 / mg
- 2024-11-19
- CAS:103300-74-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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103300-74-9
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