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ChemicalBook >> CAS DataBase List >> Pasireotide

Pasireotide

Pasireotide price.
  • $131 - $1802
  • Product name: Pasireotide
  • CAS: 396091-73-9
  • MF: C58H66N10O9
  • MW: 1047.23
  • EINECS:
  • MDL Number:MFCD08067735
  • Synonyms:PASIREOTIDE;Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl];SOM 230;SOM 320;[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate;SOM 230;SOM 320;CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY)-L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-);Pasireotide Acetate(net)
14 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Chemenu
  • DC Chemicals
  • TRC
Package
  • 500ug
  • 1MG
  • 2mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0009659
  • Product descriptionPASIREOTIDE 95.00%
  • Packaging1MG
  • Price$930.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3596
  • Product description(E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci
  • Packaging1mg
  • Price$131
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3596
  • Product description(E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci
  • Packaging5mg
  • Price$589
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3596
  • Product description(E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci
  • Packaging10mg
  • Price$1045
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611439
  • Product descriptionPasireotide
  • Packaging10mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611439
  • Product descriptionPasireotide
  • Packaging5mg
  • Price$1184.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP110151
  • Product descriptionPasireotide acetate
  • Packaging500ug
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP110151
  • Product descriptionPasireotide acetate
  • Packaging1mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP110151
  • Product descriptionPasireotide acetate
  • Packaging2mg
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFP110151
  • Product descriptionPasireotide acetate
  • Packaging5mg
  • Price$975
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM148851
  • Product description(3S,6R,9S,12S,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13,16-hexaoxo-3-phenylicosahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadecin-19-yl(2-aminoethyl)carbamate 98%
  • Packaging10mg
  • Price$914
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC22540
  • Product descriptionPasireotide >98%
  • Packaging50mg
  • Price$890
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC22540
  • Product descriptionPasireotide >98%
  • Packaging100mg
  • Price$1200
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP211010
  • Product descriptionPasireotideTFASalt
  • Packaging1mg
  • Price$580
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0009659 PASIREOTIDE 95.00% 1MG $930.3 2021-12-16 Buy
ApexBio Technology B3596 (E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci 1mg $131 2021-12-16 Buy
ApexBio Technology B3596 (E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci 5mg $589 2021-12-16 Buy
ApexBio Technology B3596 (E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci 10mg $1045 2021-12-16 Buy
Biorbyt Ltd orb611439 Pasireotide 10mg $1802 2021-12-16 Buy
Biorbyt Ltd orb611439 Pasireotide 5mg $1184.9 2021-12-16 Buy
Biosynth Carbosynth FP110151 Pasireotide acetate 500ug $150 2021-12-16 Buy
Biosynth Carbosynth FP110151 Pasireotide acetate 1mg $240 2021-12-16 Buy
Biosynth Carbosynth FP110151 Pasireotide acetate 2mg $430 2021-12-16 Buy
Biosynth Carbosynth FP110151 Pasireotide acetate 5mg $975 2021-12-16 Buy
Chemenu CM148851 (3S,6R,9S,12S,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13,16-hexaoxo-3-phenylicosahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadecin-19-yl(2-aminoethyl)carbamate 98% 10mg $914 2021-12-16 Buy
DC Chemicals DC22540 Pasireotide >98% 50mg $890 2021-12-16 Buy
DC Chemicals DC22540 Pasireotide >98% 100mg $1200 2021-12-16 Buy
TRC P211010 PasireotideTFASalt 1mg $580 2021-12-16 Buy

Properties

Boiling point :1351.4±65.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :11.86±0.46(Predicted)
Sequence :cyclo[Tyr(Bzl)-Phe-Hyp(Bom)-Phg-D-Trp-Lys]
InChIKey :VMZMNAABQBOLAK-PHODJXESNA-N
CAS DataBase Reference :396091-73-9

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

In April 2012, the European Commission approved pasireotide for the treatment of Cushing’s Disease (CD) in adult patients who have not responded to surgical interventionor forwhomsurgery is not anoption.Pasireotide was approved for the same indication by the US FDA in December of 2012. Pasireotide (also known as SOM230) is a cyclohexapeptide that acts as a somatostatin analogue to inhibit the release of ACTH. Somatostatins are cyclic peptides of 14 and 28 amino acids that play animportant role inregulating endocrineandexocrine release inmany tissues through an inhibitory mechanism. There are five known subtypes of somatostatin receptors (SSTRs). Natural somatostatins bind with high affinity to all five subtypes, however, their therapeutic use is limited by rapid degradation in plasma. Pasireotide arose fromefforts to identify a somatostatinmimetic with long-lasting inhibitory effects. Starting with a 14-amino acid somatostatin peptide, a systematic alanine scan revealed residues that were essential for receptor sub-type binding, including key b-turn regions and adjacent residues. Placing the key structural elements as unnatural amino acids in a cyclohexapeptide backbone gave pasireotide.

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