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ChemicalBook >> CAS DataBase List >> BISINDOLYLMALEIMIDE II

BISINDOLYLMALEIMIDE II

BISINDOLYLMALEIMIDE II price.
  • $55 - $1290
  • Product name: BISINDOLYLMALEIMIDE II
  • CAS: 137592-45-1
  • MF: C27H26N4O2
  • MW: 438.52
  • EINECS:
  • MDL Number:MFCD00236430
  • Synonyms:BISINDOLYLMALEIMIDE II;3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione;2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE;3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-;Bisindolylmaleimide II, PKC inhibitor
14 prices
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Brand
  • aablocks
  • Adipogen Life Sciences
  • ApexBio Technology
  • Cayman Chemical
  • CSNpharm
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 50
  • 5mg
  • 10mg
  • 50mg
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
  • Packaging1mg
  • Price$107
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
  • Packaging5mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M001
  • Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
  • Packaging1mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M005
  • Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
  • Packaging5mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimideII
  • Packaging10mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimideII
  • Packaging50mg
  • Price$1290
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
  • Packaging5mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22715
  • Product descriptionBisindolylmaleimideII
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22715
  • Product descriptionBisindolylmaleimideII
  • Packaging50mg
  • Price$655
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4128
  • Product descriptionBisindolylmaleimideII ≥97%(HPLC)
  • Packaging10
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4128
  • Product descriptionBisindolylmaleimideII ≥97%(HPLC)
  • Packaging50
  • Price$887
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB448535
  • Product descriptionBisindolylmaleimideII
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number044603
  • Product descriptionBisindolylmaleimide II
  • Packaging1mg
  • Price$295
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009AQ2 BISINDOLYLMALEIMIDEII ≥97%(isomermixture) 1mg $107 2021-12-16 Buy
aablocks AA009AQ2 BISINDOLYLMALEIMIDEII ≥97%(isomermixture) 5mg $225 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-0010-M001 BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) 1mg $55 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-0010-M005 BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) 5mg $165 2021-12-16 Buy
ApexBio Technology B7595 BisindolylmaleimideII 10mg $314 2021-12-16 Buy
ApexBio Technology B7595 BisindolylmaleimideII 50mg $1290 2021-12-16 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97% (isomer mixture) 1mg $57 2024-03-01 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97% (isomer mixture) 5mg $172 2024-03-01 Buy
CSNpharm CSN22715 BisindolylmaleimideII 5mg $112 2021-12-16 Buy
CSNpharm CSN22715 BisindolylmaleimideII 50mg $655 2021-12-16 Buy
Tocris 4128 BisindolylmaleimideII ≥97%(HPLC) 10 $216 2021-12-16 Buy
Tocris 4128 BisindolylmaleimideII ≥97%(HPLC) 50 $887 2021-12-16 Buy
TRC B448535 BisindolylmaleimideII 10mg $150 2021-12-16 Buy
Usbiological 044603 Bisindolylmaleimide II 1mg $295 2021-12-16 Buy

Properties

Boiling point :709.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
color :Yellow to orange
biological source :synthetic (organic)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 μM, BIM II inhibits 98% of PKCα kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.

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