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ChemicalBook >> CAS DataBase List >> 2'2'-cGAMP

2'2'-cGAMP

2'2'-cGAMP price.
  • $422 - $714
  • Product name: 2'2'-cGAMP
  • CAS: 1465774-27-9
  • MF: C20H24N10O13P2
  • MW: 674.411
  • EINECS:-0
  • MDL Number:
  • Synonyms:2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt;2'2'-cGAMP (sodium salt);2’2’-cGAMP;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
2 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • ManufacturerCayman Chemical
  • Product number22419
  • Product description2’2’-cGAMP (sodium salt)
  • Packaging500μg
  • Price$422
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22419
  • Product description2’2’-cGAMP (sodium salt)
  • Packaging1mg
  • Price$714
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 22419 2’2’-cGAMP (sodium salt) 500μg $422 2024-03-01 Buy
Cayman Chemical 22419 2’2’-cGAMP (sodium salt) 1mg $714 2024-03-01 Buy

Properties

Boiling point :1159.9±75.0 °C(Predicted)
Density :2.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Water: soluble
form :A crystalline solid
pka :0.88±0.70(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).