Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
![Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- price.](/CAS/GIF/217645-70-0.gif)
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- $44 - $1600
- Product name: Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
- CAS: 217645-70-0
- MF: C21H24ClFN4O3
- MW: 434.89
- EINECS:
- MDL Number:MFCD09859709
- Synonyms:Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-;(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-2-Methyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-urea;ZK811752 (BX471);(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine ZK811752 (BX471);N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea;BX471(ZK-811752);Piperazine,1-[[2-[(aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-;(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine
28 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3511AH
- Product description1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea
- Packaging250mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging5mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging10mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging25mg
- Price$566
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA434794
- Product descriptionBX 471 98+%
- Packaging50mg
- Price$735
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000393
- Product descriptionBX 471 95.00%
- Packaging5MG
- Price$499.94
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCCH0013051
- Product descriptionN-[5-CHLORO-2-[2-[(2R)-4-[(4-FLUOROPHENYL)METHYL]-2-METHYL-1-PIPERAZINYL]-2-OXOETHOXY]PHENYL]UREA 95.00%
- Packaging5MG
- Price$501.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5435
- Product descriptionBX 471
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5435
- Product descriptionBX 471
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18503
- Product descriptionBX 471 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18503
- Product descriptionBX 471 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18503
- Product descriptionBX 471 ≥98%
- Packaging10mg
- Price$257
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18503
- Product descriptionBX 471 ≥98%
- Packaging25mg
- Price$586
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM170003
- Product description(R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea 98%
- Packaging50mg
- Price$453
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3283
- Product descriptionBX 471 99.78%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3283
- Product descriptionBX 471 99.78%
- Packaging50mg
- Price$490
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3511AH | 1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea | 250mg | $421 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 5mg | $222 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 10mg | $333 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 25mg | $566 | 2021-12-16 | Buy |
| Ambeed | A434794 | BX 471 98+% | 50mg | $735 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000393 | BX 471 95.00% | 5MG | $499.94 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0013051 | N-[5-CHLORO-2-[2-[(2R)-4-[(4-FLUOROPHENYL)METHYL]-2-METHYL-1-PIPERAZINYL]-2-OXOETHOXY]PHENYL]UREA 95.00% | 5MG | $501.5 | 2021-12-16 | Buy |
| ApexBio Technology | B5435 | BX 471 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | B5435 | BX 471 | 50mg | $640 | 2021-12-16 | Buy |
| Cayman Chemical | 18503 | BX 471 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18503 | BX 471 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 18503 | BX 471 ≥98% | 10mg | $257 | 2024-03-01 | Buy |
| Cayman Chemical | 18503 | BX 471 ≥98% | 25mg | $586 | 2024-03-01 | Buy |
| Chemenu | CM170003 | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea 98% | 50mg | $453 | 2021-12-16 | Buy |
| ChemScene | CS-3283 | BX 471 99.78% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-3283 | BX 471 99.78% | 50mg | $490 | 2021-12-16 | Buy |
Properties
Boiling point :593.5±50.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
Safety Information
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Description
The CC chemokine receptor-1 (CCR1), whose ligands include macrophage inflammatory protein-1α (MIP-1α), RANTES, and monocyte chemotactic protein-3 (MCP-3), has a central role in leukocyte trafficking and is highly expressed in certain autoimmune diseases. BX 471 is a nonpeptide CCR1 antagonist that has been shown to displace MIP-1α, RANTES, and MCP-3 with Ki values of 1, 2.8, and 5.5 nM, respectively. It demonstrates >10,000-fold selectivity for CCR1 over 28 additional G protein-coupled receptors, including related chemokine receptors. In a rat experimental allergic encephalomyelitis model of multiple sclerosis, BX 471 at 50 mg/kg was shown to significantly reduce the severity of the disease. BX 471 also decreases the inflammatory response during sepsis, blocks migration of monocytes isolated from rheumatoid arthritis patients, and prevents macrophage and T-cell recruitment in a mouse model of lupus nephritis.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited
