ChemicalBook >?? ???? >?????LL-37???(??)
?????LL-37???(??)
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?????LL-37???(??) ??
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- -20°C
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- DMSO: Insoluble;Ethanol: 90 mg/mL (20.03 mM)
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- Water: 90 mg/mL (20.03 mM)
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- H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu -Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
- InChIKey
- JATXYCFPJFQHBQ-XAMSXPGMSA-N
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?????LL-37???(??) C??? ??, ??, ??
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LL-37, also known as hCAP18, belongs to the cathelicidins family of antimicrobial peptides that possess strong antimicrobial activity across multiple species. In humans, this is the only cathelicidin present, and it is produced in epithelial cells through the proteolytic cleavage of the hCAP-18 protein. In addition to its antimicrobial properties, LL-37 also plays a crucial role in regulating the immune system. It can inhibit inflammatory responses by suppressing the activation of TLR2 and TLR4, which recognize different components of bacterial cell walls.??
LL-37 is a human antimicrobial peptide of the cathelicidin family and corresponds to the 134-170 segment of human cationic antimicrobial protein 18 (hCAP18). It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is significantly resistant to proteolytic degradation in solution.Origin
LL-37 has been extensively studied since its discovery in 1995. This substance is a host defense peptide released by hCAP18 which is the only human cathelicidin.?????LL-37???(??) ?? ?? ? ???
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?????LL-37???(??) ?? ??
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?????LL-37???(??) ?? ??:
??????? ?? ?? ????????? ????? ??(2,2,6,6-?????-3,5-???????) ??????? ?2? ???(II) ????????? ?????? ???? ?????????
Tosylmethyl isocyanide
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
SALCOMINE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
PHENYLSELENOL
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Tris(2,4-pentanedionato)chroMiuM(III)
METHYL ISOCYANOACETATE
Ethyl isocyanoacetate
TERT-BUTYL ISOCYANIDE
Benzyl isocyanide
N-BUTYLISOCYANIDE