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アバナフィル

アバナフィル 化學(xué)構(gòu)造式
330784-47-9
CAS番號.
330784-47-9
化學(xué)名:
アバナフィル
別名:
アバナフィル;4-[(3-クロロ-4-メトキシベンジル)アミノ]-2-[(2S)-2-(ヒドロキシメチル)ピロリジン-1-イル]-N-(ピリミジン-2-イルメチル)ピリミジン-5-カルボキサミド;4-{[(3-クロロ-4-メトキシフェニル)メチル]アミノ}-2-[(2S)-2-(ヒドロキシメチル)ピロリジン-1-イル]-N-[(ピリミジン-2-イル)メチル]ピリミジン-5-カルボキサミド;N-(ピリミジン-2-イルメチル)-2-[(2S)-2-(ヒドロキシメチル)ピロリジノ]-4-(3-クロロ-4-メトキシベンジルアミノ)ピリミジン-5-カルボアミド;4-[(3-クロロ-4-メトキシベンジル)アミノ]-2-[(2S)-2-(ヒドロキシメチル)ピロリジノ]-N-(2-ピリミジニルメチル)ピリミジン-5-カルボアミド
英語名:
Avanafil
英語別名:
Stendra;vanafil;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;U 53;U-53;D03217;avanfil;AVANAFE;Avanafi
CBNumber:
CB91503998
化學(xué)式:
C23H26ClN7O3
分子量:
483.95
MOL File:
330784-47-9.mol

アバナフィル 物理性質(zhì)

融點 :
150-152°C
比重(密度) :
1.372
貯蔵溫度 :
Sealed in dry,Store in freezer, under -20°C
溶解性:
DMSO(微量)、メタノール(微量、加溫)
外見 :
個體
酸解離定數(shù)(Pka):
11.84±0.46(Predicted)
色:
ホワイトからオフホワイト
InChIKey:
WEAJZXNPAWBCOA-INIZCTEOSA-N
SMILES:
C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1
CAS データベース:
330784-47-9(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する聲明
  • 危険有害性情報のコード(GHS)
HSコード  29339900
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
注意書き
P280 保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。
P305+P351+P338 眼に入った場合:水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

アバナフィル 価格 もっと(3)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
富士フイルム和光純薬株式會社(wako) W01MAS118219
(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
330784-47-9 1g ¥362900 2024-03-01 購入
Sigma-Aldrich Japan SML2799 ≥98% (HPLC)
Avanafil ≥98% (HPLC)
330784-47-9 100MG ¥5310 2024-03-01 購入
Sigma-Aldrich Japan SML2799 ≥98% (HPLC)
Avanafil ≥98% (HPLC)
330784-47-9 500MG ¥15900 2024-03-01 購入

アバナフィル 化學(xué)特性,用途語,生産方法

効能

勃起不全治療薬, ホスホジエステラーゼV阻害薬

説明

Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.

化學(xué)的特性

White Solid

使用

Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.

定義

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine Used for treatment of erectile dysfunction.

臨床応用

Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).

アバナフィル 上流と下流の製品情報

原材料

準(zhǔn)備製品


アバナフィル 生産企業(yè)

Global( 480)Suppliers
名前 電話番號 電子メール 國籍 製品カタログ 優(yōu)位度
Wuhan Quanjinci New Material Co.,Ltd.
+86-15271838296; +8615271838296
kyra@quanjinci.com China 1512 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8618791163155
18791163155@163.com China 3469 58
Wuhan Mayue Longteng Technology Development Co., Ltd.
+undefined15171477138
helen.yan@lantu-tech.com China 297 58
Jinan Million Pharmaceutical Co., Ltd
0531-68659554 +8613031714605
info@millionpharm.com China 226 58
Guangzhou Tosun Pharmaceutical Ltd
+86-020-61855200-902 +8618124244216
info@upharm.cn China 897 58
Forest chemical technology
+85295407470
grant@forestchem.freeqiye.com China 735 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3058 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210
sales@cellwh.com China 376 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 1014 58
qingdao future trading Co., Ltd
+86-13335044410
cui56813@163.com China 110 58

アバナフィル  スペクトルデータ(1HNMR)


330784-47-9(アバナフィル)キーワード:


  • 330784-47-9
  • 4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
  • Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
  • avanfil
  • (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl
  • avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami
  • (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide
  • (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
  • 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
  • Avanafil
  • Avanafil (usan/inn)
  • D03217
  • Avanafil PDE5 inhibitor
  • pharmaceutical raw material suppliers Avanafil 330784-47-9 high quality lower Prices
  • Natural Sex Steroid Hormones Avanafil Hormone Powder C23H26ClN7O3 CAS 330784-47-9
  • Avanafil-d3
  • 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
  • Avanafil(TA-1790)
  • 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
  • [13C5, 15N]-Avanafil
  • 4-[(3-Chloro-4-methoxybenzyl)amino]
  • O cut the non
  • AVANAFE
  • Avanafil white powder
  • Avanafil USP/EP/BP
  • Avanafil , Stendra
  • Avanafil, Standa
  • (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
  • 4-[(3-Chloro-4-methoxybenzyl)amino] Avanafil
  • Avanafil-d4
  • (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-6-carboxamide
  • アバナフィル
  • 4-[(3-クロロ-4-メトキシベンジル)アミノ]-2-[(2S)-2-(ヒドロキシメチル)ピロリジン-1-イル]-N-(ピリミジン-2-イルメチル)ピリミジン-5-カルボキサミド
  • 4-{[(3-クロロ-4-メトキシフェニル)メチル]アミノ}-2-[(2S)-2-(ヒドロキシメチル)ピロリジン-1-イル]-N-[(ピリミジン-2-イル)メチル]ピリミジン-5-カルボキサミド
  • N-(ピリミジン-2-イルメチル)-2-[(2S)-2-(ヒドロキシメチル)ピロリジノ]-4-(3-クロロ-4-メトキシベンジルアミノ)ピリミジン-5-カルボアミド
  • 4-[(3-クロロ-4-メトキシベンジル)アミノ]-2-[(2S)-2-(ヒドロキシメチル)ピロリジノ]-N-(2-ピリミジニルメチル)ピリミジン-5-カルボアミド
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