ネダプラチン
ネダプラチン 物理性質(zhì)
- 貯蔵溫度 :
- Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
- 外見 :
- Powder
- 色:
- Light yellow to yellow
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語(yǔ) |
警告 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語(yǔ) |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P280 |
保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。 |
| P305+P351+P338 |
眼に入った場(chǎng)合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場(chǎng)合は外す こと。その後も洗浄を続けること。 |
|
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01W0114-0948 |
ネダプラチン 98.0+% (HPLC)
Nedaplatin 98.0+% (HPLC) |
95734-82-0 |
10mg |
￥17400 |
2021-03-23 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01W0114-0948 |
ネダプラチン 98.0+% (HPLC)
Nedaplatin 98.0+% (HPLC) |
95734-82-0 |
50mg |
￥59500 |
2020-09-21 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTN0212 |
ネダプラチン
Nedaplatin |
95734-82-0 |
10mg |
￥43400 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTN0212 |
ネダプラチン
Nedaplatin |
95734-82-0 |
25mg |
￥82900 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTN0212 |
ネダプラチン
Nedaplatin |
95734-82-0 |
50mg |
￥153900 |
2024-03-01 |
購(gòu)入 |
ネダプラチン 化學(xué)特性,用途語(yǔ),生産方法
溶解性
水に溶ける。
用途
DNA 鎖內(nèi)及び鎖間で DNA 架
橋を形成し、DNA の複製及び転寫阻害作用を
示します。
効能
抗悪性腫瘍薬, 細(xì)胞増殖阻害薬
商品名
アクプラ (日醫(yī)工)
説明
Nedaplatin, a novel second generation platinum complex, was marketed
in Japan for the treatment of a variety of cancers including: head and neck, small-cell
and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder,
and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been
reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which
react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and
DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more
active than cisplatin against several solid tumors while sharing less nephro- and
gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by
nedaplatin allows its use in patients with deteriorated renal function.
使用
Nedaplatin is a platinum complex that has potent antineoplatic activity.
応用例（製薬）
Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin.
The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving
groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin
has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular,
ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect
is myelosuppression.
ネダプラチン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
ネダプラチン 生産企業(yè)
Global( 225)Suppliers
95734-82-0(ネダプラチン)キーワード:
- 95734-82-0
- (glycolato-o,o')diammineplatinum(ii)
- cis-diammine(glycolato)platinum(ii)
- NEDAPLATIN
- 254-s
- o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu
- Nedaplait
- o(sup 2))- diammine(hydroxyacetato(2-)-o(sup 1 (sp-4-3)-platinu (glycolato-o,o')diammineplatinum(ii) 254-s cis-diammine(glycolato)platinum(ii) nedaplatin nsc 375101d
- 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one
- PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-, (SP-4-3)-
- (SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum
- Nedaplatin, >=99%
- cis-Diammine(glycolato(2-)O,O')platinum
- Cis-diammine-glycoloato-O,O'-platinum(II)
- platinum(2+) azanide- hydroxyacetic acid(1:2:1)
- cis-diamine-glycolate-O,O'-platinum(II)
- Aqupla
- NSC 375101D
- Nedaplatin USP/EP/BP
- Nedaplatin (NSC 375101D)
- ネダプラチン
- ネダプラチン (JAN)
- cis-ジアンミングリコラト白金