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ChemicalBook >> CAS DataBase List >>AZD-4694

AZD-4694

CAS No.
1054629-49-0
Chemical Name:
AZD-4694
Synonyms
NAV4694;AZD-4694;NAV 4694;NAV-4694;Flutafuranol;5-Benzofuranol, 2-[2-fluoro-6-(methylamino)-3-pyridinyl]-
CBNumber:
CB93333742
Molecular Formula:
C14H11FN2O2
Molecular Weight:
258.25
MDL Number:
MFCD26396130
MOL File:
1054629-49-0.mol
Last updated:2025-04-18 09:53:06

AZD-4694 Properties

Boiling point 457.2±45.0 °C(Predicted)
Density 1.381±0.06 g/cm3(Predicted)
pka 8.86±0.40(Predicted)
form Solid
color White to off-white
FDA UNII G5K506J69E

AZD-4694 Chemical Properties,Uses,Production

Uses

AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].

in vivo

Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].

Animal Model:Male Sprague–Dawley rats (275-300 g)[1]
Dosage:4 mL/kg
Administration:I.v.
Result:Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.

References

[1] Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. DOI:10.1111/j.1471-4159.2010.06812.x

AZD-4694 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD-4694 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38668 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Shanghai Chaolan Chemical Technology Center 021-QQ:65489617 15618227136 Sales@ATKchemical.com China 9347 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58

View Lastest Price from AZD-4694 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZD4694 pictures 2024-10-24 AZD4694
1054629-49-0
US $1270.00 / mg 10g TargetMol Chemicals Inc.
  • AZD4694 pictures
  • AZD4694
    1054629-49-0
  • US $1270.00 / mg
  • TargetMol Chemicals Inc.
AZD-4694 5-Benzofuranol, 2-[2-fluoro-6-(methylamino)-3-pyridinyl]- Flutafuranol NAV4694 NAV-4694 NAV 4694 1054629-49-0