AZD-4694
- CAS No.
- 1054629-49-0
- Chemical Name:
- AZD-4694
- Synonyms
- NAV4694;AZD-4694;NAV 4694;NAV-4694;Flutafuranol;5-Benzofuranol, 2-[2-fluoro-6-(methylamino)-3-pyridinyl]-
- CBNumber:
- CB93333742
- Molecular Formula:
- C14H11FN2O2
- Molecular Weight:
- 258.25
- MDL Number:
- MFCD26396130
- MOL File:
- 1054629-49-0.mol
| Boiling point | 457.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.381±0.06 g/cm3(Predicted) |
| pka | 8.86±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | G5K506J69E |
AZD-4694 Chemical Properties,Uses,Production
Uses
AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1].
in vivo
Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1].
| Animal Model: | Male Sprague–Dawley rats (275-300 g)[1] |
| Dosage: | 4 mL/kg |
| Administration: | I.v. |
| Result: | Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. |
References
[1] Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. DOI:10.1111/j.1471-4159.2010.06812.x
AZD-4694 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD-4694 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38668 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9347 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Shanghai Chaolan Chemical Technology Center | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
