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ChemicalBook >> CAS DataBase List >>KI-328

KI-328

CAS No.
930089-25-1
Chemical Name:
KI-328
Synonyms
KI-328;Carbamic acid, N-[4-[2-[[5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(phenylamino)-2-pyrimidinyl]amino]ethyl]phenyl]-, methyl ester
CBNumber:
CB92731082
Molecular Formula:
C25H25N7O3
Molecular Weight:
471.51
MDL Number:
MOL File:
930089-25-1.mol
Last updated:2025-04-29 09:03:59

KI-328 Chemical Properties,Uses,Production

Description

KI-328 is a novel KIT inhibitor. KI-328 shows selective potency against KIT kinase for the in vitro kinase assay, and inhibits the growth of wild-type (Wt)- and mutant-KIT-expressing cells, while it has little potency against D816V-KIT.

Uses

KI-328 is a novel inhibitor targeting KIT kinase that has selective activity against some KIT mutant kinases commonly found in acute myeloid leukemia (AML). KI-328 showed specificity for KIT kinase in in vitro kinase assays and inhibited the growth of wild-type (Wt) and mutant KIT-expressing cells, but had lower activity against D816V-KIT. Comparative analysis of the inhibitory effects of several potent KIT inhibitors on the growth of multiple mutant KIT-expressing cells showed that the multi-kinase inhibitors had comparable activity against D816V-KIT as against other mutant KITs; however, heat shock protein 90 (HSP90) inhibitors showed significant activity against D816V-KIT, inhibiting the growth of D816V-KIT-expressing cells at concentrations that did not affect the growth of other mutant KIT-expressing cells. These results suggest that potent KIT inhibitors have different activities against different types of KIT mutant kinases. Therefore, in clinical development, KIT inhibitors need to validate their activity against multiple types of KIT mutant kinases.

References

[1] Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia

KI-328 Preparation Products And Raw materials

Raw materials

Preparation Products

KI-328 Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 19904 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 23248 58

View Lastest Price from KI-328 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KI-328 pictures 2025-04-29 KI-328
930089-25-1
US $2180.00-1670.00 / mg 10g TargetMol Chemicals Inc.
  • KI-328 pictures
  • KI-328
    930089-25-1
  • US $2180.00-1670.00 / mg
  • TargetMol Chemicals Inc.
KI-328 Carbamic acid, N-[4-[2-[[5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(phenylamino)-2-pyrimidinyl]amino]ethyl]phenyl]-, methyl ester 930089-25-1