PDK1 Inhibitor
- CAS No.
- 850717-64-5
- Chemical Name:
- PDK1 Inhibitor
- Synonyms
- BX-517;BIX517;CS-1693;BX-517;BX 517;PDK1 Inhibitor 2;PDK1 Inhibitor II;BX517, 10 mM in DMSO;BX517(PDK1 inhibitor2);inhibit,BX517,Inhibitor,PDK-1;5-Ureido-3-[1-(pyrrol-2-yl)ethylidene]indolin-2-one
- CBNumber:
- CB92667655
- Molecular Formula:
- C15H14N4O2
- Molecular Weight:
- 282.3
- MDL Number:
- MFCD28044315
- MOL File:
- 850717-64-5.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | insoluble in H2O; insoluble in EtOH; ≥8.55 mg/mL in DMSO |
| form | solid |
| color | Light yellow to khaki |
| FDA UNII | SYV8VN8W5K |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
PDK1 Inhibitor price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 521276 | PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem | 850717-64-5 | 5mg | $167 | 2023-01-07 | Buy |
| Cayman Chemical | 29238 | BX-517 | 850717-64-5 | 5mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 29238 | BX-517 | 850717-64-5 | 50mg | $648 | 2024-03-01 | Buy |
| Cayman Chemical | 29238 | BX-517 | 850717-64-5 | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 29238 | BX-517 | 850717-64-5 | 25mg | $352 | 2024-03-01 | Buy |
PDK1 Inhibitor Chemical Properties,Uses,Production
Uses
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
Biological Activity
bx-517 is a potent and selective inhibitor of pdk1 that binds to the atp binding pocketof the protein (ic50 = 6 nm). bx-517 also blocks activation of akt in tumor cells with 10-fold more potent (ic50 = 0.1–1.0 μm) than its analogs tested at the highest dose tested (10 μm). [1] the phosphoinositide-dependent kinase-1 (pdk1) is a ser/thr kinase that is a crucial activator of a range of protein kinases in the agc kinase super-family that play key roles in the progression of cancer and for the activation of akt, s6 kinase, and protein kinase c. [2]
References
1. islam i, brown g, bryant j et al. indolinone based phosphoinositide-dependentkinase-1 (pdk1) inhibitors. part 2: optimization of bx-517. bioorg med chem lett.2007 jul 15;17(14):3819-25. 2. islam i, bryant j, chou yl etc. indolinone based phosphoinositide-dependent kinase-1 (pdk1)inhibitors. part 1: design, synthesis and biological activity. bioorg med chem lett. 2007 jul 15;17(14):3814-8.
PDK1 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32285 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38668 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
