GSK_WRN3
- CAS No.
- 2923009-50-9
- Chemical Name:
- GSK_WRN3
- Synonyms
- GSK_WRN3;3-Pyridinecarboxamide, 6-cyclohexyl-N-[(3R)-2,3-dihydro-1,1-dioxido-3-thienyl]-1,2-dihydro-5-hydroxy-2-oxo-
- CBNumber:
- CB914259499
- Molecular Formula:
- C16H20N2O5S
- Molecular Weight:
- 352.41
- MDL Number:
- MOL File:
- 2923009-50-9.mol
Last updated:2025-05-19 13:47:27
GSK_WRN3 Chemical Properties,Uses,Production
Uses
GSK_WRN3 is selective WRN helicase inhibitor (pIC50 = 8.6). SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity[1].
References
[1] Picco G, et al. Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. Cancer Discov. 2024 Apr 9. DOI:10.1158/2159-8290.CD-24-0052
GSK_WRN3 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK_WRN3 Suppliers
Global( 1)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
GSK_WRN3
3-Pyridinecarboxamide, 6-cyclohexyl-N-[(3R)-2,3-dihydro-1,1-dioxido-3-thienyl]-1,2-dihydro-5-hydroxy-2-oxo-
2923009-50-9