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ChemicalBook >> CAS DataBase List >>(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine

CAS No.
2412056-27-8
Chemical Name:
(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine
Synonyms
Thalidomide-5-NH-C1-COOH;Thalidomide-5-NH2-CH2-COOH;(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine;inhibit,cancer,Thalidomide,E3 ligase,inflammatory,infectious,Thalidomide-5-NH-2-CH2-COOH,trk,Thalidomide5NH2CH2COOH,Inhibitor,tropomyosin receptor kinase,E3 ligase-recruiting Moiety,neurodegenerative,Thalidomide 5 NH2 CH2 COOH,selective,Ligands for E3 Ligase
CBNumber:
CB89638141
Molecular Formula:
C15H13N3O6
Molecular Weight:
331.28
MDL Number:
MOL File:
2412056-27-8.mol
Last updated:2024-11-19 23:02:33

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Properties

solubility DMSO : 33.33 mg/mL (100.61 mM; Need ultrasonic)
form Solid
color Light yellow to green yellow
InChI InChI=1S/C15H13N3O6/c19-11-4-3-10(13(22)17-11)18-14(23)8-2-1-7(16-6-12(20)21)5-9(8)15(18)24/h1-2,5,10,16H,3-4,6H2,(H,20,21)(H,17,19,22)
InChIKey ZATMCTCUKSYXHM-UHFFFAOYSA-N
SMILES O=C1C2=CC(NCC(=O)O)=CC=C2C(=O)N1C1CCC(=O)NC1=O

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Chemical Properties,Uses,Production

Biological Activity

Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1)[1].

References

[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. Patent WO2021170109A1.

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Preparation Products And Raw materials

Raw materials

Preparation Products

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Suppliers

Global( 17)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6791 65
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1464 58
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725 malulu@leyan.com China 54987 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4326 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80514535 19917294565 caoy@chemextension.com China 4752 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62075 58
Affinity（Wuhan）Ltd. 15841022315 sales@affinitytech.cn China 3000 58

View Lastest Price from (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thalidomide-5-NH2-CH2-COOH pictures 2024-11-19 Thalidomide-5-NH2-CH2-COOH
2412056-27-8
 US $42.00-139.00 / mg 95.95% 10g TargetMol Chemicals Inc.

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Spectrum

(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine Thalidomide-5-NH2-CH2-COOH inhibit,cancer,Thalidomide,E3 ligase,inflammatory,infectious,Thalidomide-5-NH-2-CH2-COOH,trk,Thalidomide5NH2CH2COOH,Inhibitor,tropomyosin receptor kinase,E3 ligase-recruiting Moiety,neurodegenerative,Thalidomide 5 NH2 CH2 COOH,selective,Ligands for E3 Ligase Thalidomide-5-NH-C1-COOH 2412056-27-8