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ChemicalBook >> CAS DataBase List >>3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-

CAS No.
2323027-38-7
Chemical Name:
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-
Synonyms
Ceapin-A7;N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide;3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-;UPR,Inhibitor,CeapinA7,stress,unfolded protein response,reticulum,Golgi,endoplasmic,Ceapin-A7,ATF6-alpha,inhibit,Ceapin-A-7,Ceapin A7,trafficking
CBNumber:
CB88095583
Molecular Formula:
C20H12F6N4O3
Molecular Weight:
470.32
MDL Number:
MFCD31567506
MOL File:
2323027-38-7.mol
Last updated:2023-09-20 16:43:00

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Properties

storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
color White
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Chemical Properties,Uses,Production

Description

Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6? or SREBP or the IRE1 or PERK branches of the UPR.? Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.

storage

Store at -20°C

References

Gallagher et al. (2016), Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife 5 e11878 Torres et al. (2019), Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether; eLife 8 e46595

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Suppliers

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3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Spectrum

2323027-38-7(3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-)Related Search:

3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Ceapin-A7 N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide UPR,Inhibitor,CeapinA7,stress,unfolded protein response,reticulum,Golgi,endoplasmic,Ceapin-A7,ATF6-alpha,inhibit,Ceapin-A-7,Ceapin A7,trafficking 2323027-38-7 C20H12F6N4O3