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ChemicalBook >> CAS DataBase List >>3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE

CAS No.
91940-87-3
Chemical Name:
3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
Synonyms
UL-FS49;ULFS 49CL;Zatebradine HCl;ZATEBRADINE HYDROCHLORIDE;Zatebradine HCl (UL-FS-49;Zatebradine dihydrochloride;Zatebradine hydrochloride, 10 mM in DMSO;3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride;3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE;7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
CBNumber:
CB8727004
Molecular Formula:
C26H37ClN2O5
Molecular Weight:
493.04
MDL Number:
MFCD06798356
MOL File:
91940-87-3.mol
MSDS File:
SDS
Last updated:2025-06-03 22:00:04

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Properties

Melting point 188° and mp 168°
storage temp. 2-8°C
solubility H2O: ~14 mg/mL
form solid
color white
Water Solubility Soluble in water (100mM)
FDA UNII WJB7DYV16A
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z0127 Zatebradine hydrochloride ≥98% (HPLC), powder 91940-87-3 10mg $268 2024-03-01 Buy
Sigma-Aldrich Z0127 Zatebradine hydrochloride ≥98% (HPLC), powder 91940-87-3 50mg $606 2024-03-01 Buy
Cayman Chemical 18608 Zatebradine (hydrochloride) ≥95% 91940-87-3 5mg $106 2024-03-01 Buy
Cayman Chemical 18608 Zatebradine (hydrochloride) ≥95% 91940-87-3 10mg $178 2024-03-01 Buy
Cayman Chemical 18608 Zatebradine (hydrochloride) ≥95% 91940-87-3 25mg $388 2024-03-01 Buy
Product number Packaging Price Buy
Z0127 10mg $268 Buy
Z0127 50mg $606 Buy
18608 5mg $106 Buy
18608 10mg $178 Buy
18608 25mg $388 Buy

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

ZATEBRADINE HYDROCHLORIDE,Boenhringer Ingelheim

Uses

Zatebradine Hydrochloride exhibits bradycardic properties and blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN). It is also a sinus node inhibitor.

Manufacturing Process

A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3- (N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar. After the catalyst had been filtered off, the solvent was evaporated in vacuum, and the residue was taken up in methylene chloride. After the solution had been extracted with an aqueous sodium bicarbonate solution and washed with water, it was dried over magnesium sulfate, evaporated and purified over silica gel with methylene chloride and then with increasing amounts of methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of theory. Melting point: 110°C (dec.).
1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of 3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10 mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring was continued for 48 h at room temperature. After evaporating the solution in vacuum, the residue was taken up in dilute hydrochloric acid and extracted twice with ether. Subsequently, the aqueous phase was made alkaline and extracted three times with methylene chloride, and the organic phase was evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5- tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4- dimethoxyphenyl}ethyl)amino]propane was obtained.

Therapeutic Function

Bradycardic

Biological Activity

Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current (I f ) in sinoatrial node cells (EC 50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC 50 of 13.4 μ M).

Biochem/physiol Actions

Zatebradine is a bradycardiac agent.

storage

+4°C (desiccate)

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Suppliers

Global( 75)Suppliers
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TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32282 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38665 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80

View Lastest Price from 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Zatebradine hydrochloride pictures 2025-06-03 Zatebradine hydrochloride
91940-87-3
 US $45.00-157.00 / mg 97% 10g TargetMol Chemicals Inc.
Zatebradine hydrochloride pictures 2025-06-03 Zatebradine hydrochloride
91940-87-3
 US $45.00-157.00 / mg 97% 10g TargetMol Chemicals Inc.

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Spectrum

91940-87-3(3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE)Related Search:

UL-FS49 ZATEBRADINE HYDROCHLORIDE UL-FS49, 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE 2H-3-Benzazepin-2-one, 3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride Zatebradine HCl ULFS 49CL Zatebradine dihydrochloride 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride 3-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride Zatebradine HCl (UL-FS-49 Zatebradine hydrochloride, 10 mM in DMSO 91940-87-3 C26H36N2O5HCl C26H37ClN2O5 Ion transporter and other ion channel