CBP-IN-1
- CAS No.
- 2222941-37-7
- Chemical Name:
- CBP-IN-1
- Synonyms
- CCS-1477;CCS147;CCS1477;CBP-IN-1;Inobrodib;CBP inhibitor 1;CBP-IN-1 (CCS1477);CCS-1477(CBP-IN-1);CCS-1477 (CCS1477);Inobrodib (CCS1477)
- CBNumber:
- CB85419700
- Molecular Formula:
- C30H32F2N4O3
- Molecular Weight:
- 534.6
- MDL Number:
- MFCD32062689
- MOL File:
- 2222941-37-7.mol
Boiling point | 761.0±60.0 °C(Predicted) |
---|---|
Density | 1.37±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Ethanol:100.0(Max Conc. mg/mL);187.06(Max Conc. mM) |
form | A solid |
pka | 4.40±0.10(Predicted) |
color | White to off-white |
FDA UNII | BW5QA5GEW7 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 |
CBP-IN-1 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0091862 | CBP/p300-IN-4 99.83% | 2222941-37-7 | 5mg | $230 | 2021-12-16 | Buy |
ChemScene | CS-0091862 | CBP/p300-IN-4 99.83% | 2222941-37-7 | 50mg | $1200 | 2021-12-16 | Buy |
DC Chemicals | DC31451 | CCS-1477 | 2222941-37-7 | 250mg | $1300 | 2021-12-16 | Buy |
DC Chemicals | DC31451 | CCS-1477 | 2222941-37-7 | 1g | $2600 | 2021-12-16 | Buy |
DC Chemicals | DC31451 | CCS-1477 | 2222941-37-7 | 100mg | $700 | 2021-12-16 | Buy |
CBP-IN-1 Chemical Properties,Uses,Production
Uses
(6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone is used for the treatment of genetic disease related to the expression of c9orf72 (brain expressed, associated with NEDD4)
in vivo
Inobrodib (10-30 mg/kg; oral gavage; 10 or 20 mg/kg daily (QD) or 30 mg/kg every other day (QOD) for 28 days) suppresses growth of a 22Rv1 mouse xenograft model with associated reduction in AR signaling[1].
?
Inobrodib (20 mg/kg; oral gavage; daily for 8 days) decreases AR and AR-V7 signaling and inhibits growth in a patient- derived model of lethal prostate cancer (NOD/SCID gamma (NSG) male castrated mice)[1].
Animal Model: | Noncastrated male athymic nude mice[1] |
Dosage: | 10-30 mg/kg |
Administration: | Oral gavage; at 10 or 20 mg/kg daily (QD) or at 30 mg/kg every other day (QOD) for 28 days |
Result: | Affected tumor growth at 10 mg/kg daily, 20 mg/kg daily, and 30 mg/kg every other day. |
CBP-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
CBP-IN-1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32293 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38670 | 58 | |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |