午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> CAS DataBase List >>CP-4126/CO-101

CP-4126/CO-101

CAS No.
2918768-08-6
Chemical Name:
CP-4126/CO-101
Synonyms
CP-4126/CO-101;CP-4126 hydrochloride;Gemcitabine elaidate hydrochloride, 10 mM in DMSO
CBNumber:
CB813920827
Molecular Formula:
C27H43F2N3O5.ClH
Molecular Weight:
564.11
MDL Number:
MOL File:
2918768-08-6.mol
Last updated:2025-04-18 09:52:56

CP-4126/CO-101 Properties

form Solid
color White to off-white

CP-4126/CO-101 Chemical Properties,Uses,Production

Uses

Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity[1][2].

in vivo

Gemcitabine elaidate (25-120 mg/kg; i.p. every 3 days for 5 doses) hydrochloride inhibits the solid tumor xenografts growth of non-small cell lung cancer (EKVX), non-classifiable sarcoma (MHMX), fibrous histiocytoma (TAX II-1), malignant melanoma (THX), prostate cancer (CRL-1435), pancreatic cancer (PANC-1)[1].
? Gemcitabine elaidate (10-20 mg/kg; p.o. every 3 days for 5 doses) hydrochloride shows acceptable toxicity and significant antitumor activity in the colon cancer xenograft Co6044 bearing mice[1].
? Gemcitabine elaidate (p.o. once daily for 5 doses) hydrochloride shows a favorable toxicity and antitumor activity, while the dose of 15 mg/kg is highly toxic in the human colon cancer xenograft Co6044[1].

Animal Model:Female BALB/c nude (nu/nu) mice (5-8 weeks; 20-27 g) were bearing tumor of EKVX, H-146, MHMX, TAX II-1, OHS, THX, MA-11, CRL-1435, PANC-1 and MiaPaCa-2, respectively[1]
Dosage:25-120 mg/kg
Administration:I.p. every 3 days for 5 doses
Result:Inhibited the growth of EKVX, MHMX, TAX II-1, THX, CRL-1435 and PANC-1, with T/C values of 7%, 1%, 30%, 7%, 9%, and 12%, respectively.

References

[1] Bergman AM, et, al. Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2011 Jun;29(3):456-66. DOI:10.1007/s10637-009-9377-7
[2] Adema AD, et, al. Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36(1):285-94. PMID:19956857

CP-4126/CO-101 Preparation Products And Raw materials

Raw materials

Preparation Products

CP-4126/CO-101 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32291 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9985 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4621 55
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2673 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6191 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5530 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13011 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58

View Lastest Price from CP-4126/CO-101 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gemcitabine elaidate hydrochloride pictures 2024-11-19 Gemcitabine elaidate hydrochloride
2918768-08-6
 US $31.00-97.00 / mg 99.6% 10g TargetMol Chemicals Inc.
CP-4126/CO-101 CP-4126 hydrochloride Gemcitabine elaidate hydrochloride, 10 mM in DMSO 2918768-08-6