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ChemicalBook >> CAS DataBase List >>L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]-

L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]-

CAS No.
564482-79-7
Chemical Name:
L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]-
Synonyms
DCFBC;L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]-
CBNumber:
CB810610372
Molecular Formula:
C16H19FN2O7S
Molecular Weight:
402.39
MDL Number:
MOL File:
564482-79-7.mol
Last updated:2025-04-18 09:52:46

L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]- Properties

Boiling point 732.6±60.0 °C(Predicted)
Density 1.480±0.06 g/cm3(Predicted)
pka 3.47±0.10(Predicted)
FDA UNII 40R868KZFF

L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]- Chemical Properties,Uses,Production

Uses

DCFBC is a prostate-specific membrane antigen (PSMA) inhibitor that can be used for small animal positron emission tomography (PET) imaging. DCFBC labeled with F18 ([18F]DCFBC) can images in severe combined immunodeficient mice. [18F]DCFBC uptake is higher in PIP tumors, but almost absent in FLU tumors. [18F]DCFBC uptake is also high in the kidney and bladder, but the radioactivity washout time is shorter than that in PIP tumors. Indicating that [18F]DCFBC can specifically localize to PSMA+ expressing tumors and is applicable to the study of prostate cancer[1].

References

[1] Mease RC, et al. N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin Cancer Res. 2008 May 15;14(10):3036-43. DOI:10.1158/1078-0432.CCR-07-1517

L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]- Suppliers

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TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32284 58
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L-Glutamic acid, N-[[[(1R)-1-carboxy-2-[[(4-fluorophenyl)methyl]thio]ethyl]amino]carbonyl]- DCFBC 564482-79-7 C16H19FN2O7S