L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-
![L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl- Structure](CAS/20210305/GIF/932391-88-3.gif)
- CAS No.
- 932391-88-3
- Chemical Name:
- L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-
- Synonyms
- L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-
- CBNumber:
- CB810476662
- Molecular Formula:
- C69H99N19O20
- Molecular Weight:
- 1514.64
- MDL Number:
- MOL File:
- 932391-88-3.mol
L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl- Chemical Properties,Uses,Production
Uses
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro[1].
Biological Activity
SARS-CoV Mpro FRET substrate. The MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 substrate sequence is derived from residues P4–P5' of the SARS-CoV Mpro N-terminal autoprocessing site (AVLQSGFRK). Enzymatic cleavage between Q4 and S5 of MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 releases the highly fluorescent 7-methoxycoumarin (Mca) group from the influence of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large fluorescence intensity increase. This peptide is suitable to measure protease activity of the Mpro & SARS-CoV Mpro COVID-19 viruses in addition to other viruses.
storage
-20°C
References
[1] Su HX, et al. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacol Sin. 2020 Sep;41(9):1167-1177. DOI:10.1038/s41401-020-0483-6
L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7061 | 58 |
| Hangzhou Go Top Peptide Biotech | 15397062932 | sales1@gotopbio.com | China | 2886 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-88211921 19105816207 | sales4@gotopbio.com | China | 5146 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6628 | 58 |
| Hangzhou Baige Pharmaceutical Technology Co. , Ltd. | 0571-85350119 15888826472 | 15888826472@163.com | China | 2729 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
| Combio (Suzhou) Ltd. | 0512-0512-51886999 17706251929 | office@combiosz.com | China | 3002 | 58 |
| Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211951 13735575465 | sales1@gotopbio.com | China | 4880 | 58 |
| Taiyuan Bailihengkang Biotechnology Co., Ltd | 19135651983 19135651983 | 18611134419@163.com | China | 4416 | 58 |