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ChemicalBook >> CAS DataBase List >>Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-

CAS No.
2489196-70-3
Chemical Name:
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
Synonyms
mTOR-IN-8;mTOR inhibitor-8;mTOR inhibitor-8, 10 mM in DMSO;Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
CBNumber:
CB78379626
Molecular Formula:
C24H19ClN4OS
Molecular Weight:
446.95
MDL Number:
MOL File:
2489196-70-3.mol
Last updated:2025-04-17 18:22:24

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Properties

Boiling point 626.0±65.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (55.93 mM; Need ultrasonic)
pka 3.00±0.10(Predicted)
form Solid
color White to yellow

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0133446 mTORinhibitor-8 98.04% 2489196-70-3 5mg $300 2021-12-16 Buy
ChemScene CS-0133446 mTORinhibitor-8 98.04% 2489196-70-3 10mg $480 2021-12-16 Buy
ChemScene CS-0133446 mTORinhibitor-8 98.04% 2489196-70-3 25mg $950 2021-12-16 Buy
ChemScene CS-0133446 mTORinhibitor-8 98.04% 2489196-70-3 50mg $1450 2021-12-16 Buy
ChemScene CS-0133446 mTORinhibitor-8 98.04% 2489196-70-3 100mg $2250 2021-12-16 Buy
Product number Packaging Price Buy
CS-0133446 5mg $300 Buy
CS-0133446 10mg $480 Buy
CS-0133446 25mg $950 Buy
CS-0133446 50mg $1450 Buy
CS-0133446 100mg $2250 Buy

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Chemical Properties,Uses,Production

Uses

mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1].

Biological Activity

mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1]. mTOR inhibitor-8 (Compound 5e; 0.1-10 μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner[1].mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10 μM; 3-24 hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced[1].mTOR inhibitor-8 (10 μM; 3-24 hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1] mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1].

in vivo

mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1].

Animal Model:Fertile chicken eggs (7-9 days old)[1]
Dosage:25 and 50 μM
Administration:6 days
Result:Significant xenograft tumor remission was observed in eggs compared with the DMSO-treated eggs.

IC 50

mTOR; Autophagy

References

[1]. ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551.

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6448 55
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com; 18616537568 hanfangpharma@126.com China 29980 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13012 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- mTOR inhibitor-8 mTOR-IN-8 mTOR inhibitor-8, 10 mM in DMSO 2489196-70-3