Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
- CAS No.
- 2489196-70-3
- Chemical Name:
- Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
- Synonyms
- mTOR-IN-8;mTOR inhibitor-8;mTOR inhibitor-8, 10 mM in DMSO;Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
- CBNumber:
- CB78379626
- Molecular Formula:
- C24H19ClN4OS
- Molecular Weight:
- 446.95
- MDL Number:
- MOL File:
- 2489196-70-3.mol
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Properties
Boiling point | 626.0±65.0 °C(Predicted) |
---|---|
Density | 1.35±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : 25 mg/mL (55.93 mM; Need ultrasonic) |
pka | 3.00±0.10(Predicted) |
form | Solid |
color | White to yellow |
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 5mg | $300 | 2021-12-16 | Buy |
ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 10mg | $480 | 2021-12-16 | Buy |
ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 25mg | $950 | 2021-12-16 | Buy |
ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 50mg | $1450 | 2021-12-16 | Buy |
ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 100mg | $2250 | 2021-12-16 | Buy |
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Chemical Properties,Uses,Production
Uses
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1].
Biological Activity
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1]. mTOR inhibitor-8 (Compound 5e; 0.1-10 μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner[1].mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10 μM; 3-24 hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced[1].mTOR inhibitor-8 (10 μM; 3-24 hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1] mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1].
in vivo
mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1].
Animal Model: | Fertile chicken eggs (7-9 days old)[1] |
Dosage: | 25 and 50 μM |
Administration: | 6 days |
Result: | Significant xenograft tumor remission was observed in eggs compared with the DMSO-treated eggs. |
IC 50
mTOR; Autophagy
References
[1]. ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551.
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6448 | 55 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
Nantong Hanfang Biotechnology Co. , Ltd. | hanfangpharma@126.com; 18616537568 | hanfangpharma@126.com | China | 29980 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13012 | 58 |
Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |