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ChemicalBook >> CAS DataBase List >>(+/-)11-HDOHE

(+/-)11-HDOHE

CAS No.
87018-59-5
Chemical Name:
(+/-)11-HDOHE
Synonyms
(±)11-HDHA;(±)11-HDoHE;(+/-)11-HDOHE;(+/-)11-HDOHE;LTERDCBCHFKFRI-BGKMTWLOSA-N;11-HYDROXY DOCOSAHEXAENOIC ACID;11-Hydroxy-4(Z),7(Z),9(E),13(Z),16(Z),19(Z)-DHA;(+/-)11-HYDROXY-4Z,7Z,9E,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID;4,7,9,13,16,19-Docosahexaenoic acid, 11-hydroxy-, (4Z,7Z,9E,13Z,16Z,19Z)-
CBNumber:
CB7439991
Molecular Formula:
C22H32O3
Molecular Weight:
344.49
MDL Number:
MFCD02262229
MOL File:
87018-59-5.mol
Last updated:2024-10-23 13:36:13

(+/-)11-HDOHE Properties

storage temp. Store at -20°C
solubility 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger
NFPA 704
3
0 0

(+/-)11-HDOHE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 33450 (±)11-HDHA ≥98% 87018-59-5 25μg $77 2024-03-01 Buy
Cayman Chemical 33450 (±)11-HDHA ≥98% 87018-59-5 50μg $144 2024-03-01 Buy
Cayman Chemical 33450 (±)11-HDHA ≥98% 87018-59-5 100μg $273 2024-03-01 Buy
Cayman Chemical 33450 (±)11-HDHA ≥98% 87018-59-5 250μg $602 2024-03-01 Buy
TRC H999770 (+/-)11-HDoHE 87018-59-5 25μg $70 2021-12-16 Buy
Product number Packaging Price Buy
33450 25μg $77 Buy
33450 50μg $144 Buy
33450 100μg $273 Buy
33450 250μg $602 Buy
H999770 25μg $70 Buy

(+/-)11-HDOHE Chemical Properties,Uses,Production

Description

(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.1,2 It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.3,4,5 DHA is metabolized to 11(S)-HDHA by human platelets and canine retina.6,7,8,5 In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.6,8,5 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respectively.8,9 (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

Uses

(+/-)11-HDoHE is a potential marker of oxidative stress.

Definition

ChEBI: 11-HDoHE is a hydroxydocosahexaenoic acid that consists of 4Z,7Z,9E,13Z,16Z,19Z-docosahexaenoic acid with the hydroxy group located at position 11. It has a role as a metabolite.

References

1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Reynaud, D., Thickitt, C.P., and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation Anal. Biochem. 214(1),165-170(1993).
3. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
4. Yamane, M., Abe, A., and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate J. Chromatogr. 652(2),123-136(1994).
5. Kim, H.Y., Karanian, J.W., Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate Prostaglandins 40(5),473-490(1990).
6. Avelda?o, M.I., and Sprecher, H. Synthesis of hydroxy fatty acids from 4,7,10,13,16,19-[1-14C] docosahexaenoic acid by human platelets J. Biol. Chem. 258(15),9339-9343(1983).
7. Bazan, N.G., Birkle, D.L., and Reddy, T.S. Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina Biochem. Biophys. Res. Commun. 125(2),741-747(1984).
8. Lagarde, M., Croset, M., Guichardant, M., et al. Role of lipoxygenase products in platelet function: Relation to fatty acid modified phospholipids Adv. Exp. Med. Biol. 192,327-335(1985).
9. Karanian, J.W., Kim, H.Y., and Salem, N., Jr. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction J. Pharmacol. Exp. Ther. 270(3),1105-1109(1994).

(+/-)11-HDOHE Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)11-HDOHE Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32267 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 25003 65
Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1977 58
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9171 60
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58

View Lastest Price from (+/-)11-HDOHE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(±)11-HDHA pictures 2024-10-24 (±)11-HDHA
87018-59-5
 US $1500.00 / μg 10g TargetMol Chemicals Inc.
  • (±)11-HDHA pictures
  • (±)11-HDHA
    87018-59-5
  • US $1500.00 / μg
  • TargetMol Chemicals Inc.
11-HYDROXY DOCOSAHEXAENOIC ACID (+/-)11-HDOHE (±)11-HDHA (+/-)11-HYDROXY-4Z,7Z,9E,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID LTERDCBCHFKFRI-BGKMTWLOSA-N 4,7,9,13,16,19-Docosahexaenoic acid, 11-hydroxy-, (4Z,7Z,9E,13Z,16Z,19Z)- (+/-)11-HDOHE 11-Hydroxy-4(Z),7(Z),9(E),13(Z),16(Z),19(Z)-DHA (±)11-HDoHE 87018-59-5