SB 201146
- CAS No.
- 141311-11-7
- Chemical Name:
- SB 201146
- Synonyms
- SB 201146;(E)-3-[6-[(3-aminophenyl)sulfinylmethyl]-3-[8-(4-methoxyphenyl)octoxy]pyridin-2-yl]prop-2-enoate
- CBNumber:
- CB71371236
- Molecular Formula:
- C30H35LiN2O5S
- Molecular Weight:
- 542.6153
- MDL Number:
- MOL File:
- 141311-11-7.mol
SB 201146 Chemical Properties,Uses,Production
Description
SB 201146 is a leukotriene B4 antagonist. SB 201146 is a trisubstituted pyridine with high affinity for the LTB4 receptor.
Uses
SB 201146 is an LTB4 receptor antagonist with a potency range of 10 pM to 1 μM that plays a critical role in asthma-associated airway inflammation. Studies have focused on its effects on eosinophil survival, a hallmark of asthma pathology. Studies have shown that eosinophil-derived cysteinyl leukotrienes, including LTC4 and LTD4, as well as factors such as GM-CSF and fibronectin promote eosinophil survival. SB 201146 effectively reversed mast cell- and lymphocyte-induced eosinophil survival, highlighting its potential therapeutic role in disrupting the autocrine cysteinyl leukotriene pathway that maintains eosinophil viability. This antagonist also highlights the importance of LTB4 as a paracrine mediator that influences eosinophil survival in inflammatory settings such as asthma[1].
References
[1] Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
SB 201146 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 201146 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32295 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21630 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |