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ChemicalBook >> CAS DataBase List >>4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid

CAS No.
171746-21-7
Chemical Name:
4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid
Synonyms
CD 3106;AGN 193109;AGN 193109 SodiuM Salt;AGN 193109, 10 mM in DMSO;4-((5,5-Dimethyl-8-p-tolyl-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid;4-{[5,5-diMethyl-8-(4-Methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid;4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid;Benzoic acid, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-;AGN193109,Autophagy,Inhibitor,Retinoic acid receptors,Retinoid X receptors,RAR/RXR,AGN 193109,AGN-193109,inhibit
CBNumber:
CB71359968
Molecular Formula:
C28H24O2
Molecular Weight:
392.49
MDL Number:
MFCD00943817
MOL File:
171746-21-7.mol
Last updated:2025-01-27 09:38:02

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Properties

Melting point 246-255?C
Boiling point 564.5±50.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly, Heated), DMSO (Slightly, Sonicated)
form Solid
pka 4.08±0.10(Predicted)
color Off-White to Pale Yellow
Stability Hygroscopic
FDA UNII ZC6062V1O9
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23975 AGN 193109 (sodium salt) 171746-21-7 500μg $107 2023-01-06 Buy
Cayman Chemical 23975 AGN 193109 (sodium salt) 171746-21-7 1mg $204 2023-01-06 Buy
Tocris 5758 AGN193109 ≥98%(HPLC) 171746-21-7 10 $303 2021-12-16 Buy
TRC A427000 AGN193109SodiumSalt 171746-21-7 10mg $1455 2021-12-16 Buy
TRC A427000 AGN193109SodiumSalt 171746-21-7 1mg $185 2021-12-16 Buy
Product number Packaging Price Buy
23975 500μg $107 Buy
23975 1mg $204 Buy
5758 10 $303 Buy
A427000 10mg $1455 Buy
A427000 1mg $185 Buy

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

As a retinoic acid receptor (RAR) antagonist, 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid can be used for treating chemotherapy and radiation therapy side effects.

Biological Activity

AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist th at targets all three RAR subtypes with higher affinity (RARα/β/γ Kd = 2 nM) than all-trans retinoic acid/ATRA (RARα/β/γ Kd = 9/12/19 nM). AGN 193109 potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells (by 85%, 62%, and 100%, respectively, by equal molar AGN 193109 against ATRA). AGN 193109 is also widely employeed to block RAR-mediated physiological and pathalogical processes in mice and rats in vivo via oral (1-10 mg/kg) or topical (0.3-36 μmol/kg) administration.

storage

Store at -20°C

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 874 55
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3899 58

View Lastest Price from 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AGN 193109 pictures 2024-11-19 AGN 193109
171746-21-7
 US $62.00-155.00 / mg 99.89% 10g TargetMol Chemicals Inc.
  • AGN 193109 pictures
  • AGN 193109
    171746-21-7
  • US $62.00-155.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.

171746-21-7(4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid)Related Search:

AGN 193109 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid CD 3106 4-((5,5-Dimethyl-8-p-tolyl-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid 4-{[5,5-diMethyl-8-(4-Methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid AGN 193109 SodiuM Salt Benzoic acid, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]- AGN193109,Autophagy,Inhibitor,Retinoic acid receptors,Retinoid X receptors,RAR/RXR,AGN 193109,AGN-193109,inhibit AGN 193109, 10 mM in DMSO 171746-21-7 Aromatics Compounds Aromatics Intermediates & Fine Chemicals Pharmaceuticals