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ChemicalBook >> CAS DataBase List >>(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid

CAS No.
914804-63-0
Chemical Name:
(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid
Synonyms
8-iso-15-keto-PGE2;Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,8β,11α,13E)-;(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid;(Z)-7-((1S,2R,3R)-3-hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
CBNumber:
CB71235657
Molecular Formula:
C20H30O5
Molecular Weight:
350.45
MDL Number:
MFCD05863945
MOL File:
914804-63-0.mol
Last updated:2023-06-08 09:03:09

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Properties

Boiling point 534.4±50.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
solubility DMF: 33 mg/ml; DMSO: 20 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 1.4 mg/ml
pka 4.75±0.10(Predicted)

SAFETY

Risk and Safety Statements

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14390 8-iso-15-keto Prostaglandin E2 ≥98% 914804-63-0 100μg $21 2024-03-01 Buy
Cayman Chemical 14390 8-iso-15-keto Prostaglandin E2 ≥98% 914804-63-0 500μg $89 2024-03-01 Buy
Cayman Chemical 14390 8-iso-15-keto Prostaglandin E2 ≥98% 914804-63-0 1mg $157 2024-03-01 Buy
Cayman Chemical 14390 8-iso-15-keto Prostaglandin E2 ≥98% 914804-63-0 5mg $680 2024-03-01 Buy
Product number Packaging Price Buy
14390 100μg $21 Buy
14390 500μg $89 Buy
14390 1mg $157 Buy
14390 5mg $680 Buy

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Chemical Properties,Uses,Production

Description

8-iso-15-keto Prostaglandin E2 (8-iso-15-keto PGE2) is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids.1 8-iso-15-keto PGE2 is the theoretical first metabolite of 8-iso PGE2 via the 15-hydroxy PGDH pathway. While a number of potent biological activities have been attributed to 8-iso PGE2,2 there are no published reports at this time regarding its metabolism.

Definition

ChEBI: 8-iso-15-keto-PGE2 is a prostanoid.

References

1. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc. Natl. Acad. Sci. USA 87(23),9383-9387(1990).
2. Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor Prostaglandins 48,247-256(1994).

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1990 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
(Z)-7-[(1S,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid 8-iso-15-keto-PGE2 (Z)-7-((1S,2R,3R)-3-hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,8β,11α,13E)- 914804-63-0
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