1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-
![1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)- Structure](CAS/20200611/GIF/2114324-48-8.gif)
- CAS No.
- 2114324-48-8
- Chemical Name:
- 1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-
- Synonyms
- Danavorexton;1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-
- CBNumber:
- CB68092513
- Molecular Formula:
- C21H32N2O5S
- Molecular Weight:
- 424.55
- MDL Number:
- MOL File:
- 2114324-48-8.mol
1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)- Properties
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | White to off-white |
| FDA UNII | 1QMD83K4YN |
1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)- Chemical Properties,Uses,Production
Uses
Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4].
in vivo
Danavorexton (1, 10 mg/kg or 1, 3 mg/kg, subcutaneous injection) dose-dependent enhanced arousal in common marmosets and cynomolgus monkeys[2].
| Animal Model: | Common marmosets and cynomolgus monkeys models[2] |
| Dosage: | 1, 10 mg/kg (1, 3 mg/kg) |
| Administration: | s.c. |
| Result: | Decreased SWS I (Sleeping With Sirens I), SWS II (Sleeping With Sirens II) and REM (Rapid Eye Movement) sleep time. |
References
[1] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 34, No. 2, 2020.
[2] Evans R, et al. Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals. J Sleep Res. 2023 Oct;32(5):e13878 DOI:10.1111/jsr.13878
[3] Ishikawa T, et al. Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model. Pharmacol Biochem Behav. 2022 Oct;220:173464. DOI:10.1016/j.pbb.2022.173464
[4] Fujimoto T, et al. Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. DOI:10.1021/acsmedchemlett.1c00626
1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)- Preparation Products And Raw materials
Raw materials
Preparation Products
1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
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| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3000 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9995 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24898 | 58 |
| mahaloong | +86-028-81192082 +86-18180560816 | sales@mahaloong.com | China | 595 | 58 |
| Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. | 13771642864 | snhuyu_2008@126.com | China | 1131 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 10152 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |