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ChemicalBook >> CAS DataBase List >>2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

CAS No.
1218942-37-0
Chemical Name:
2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
Synonyms
CS-1795;GKT-831;GKT137831;Setanaxib;GSK-137831;GKT137831, >=98%;Setanaxib GKT137831;GKT137831(Setanaxib);GKT-137831;GKT 137831;Setanaxib, 10 mM in DMSO
CBNumber:
CB62672829
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.85
MDL Number:
MFCD27923122
MOL File:
1218942-37-0.mol
MSDS File:
SDS
Last updated:2025-06-19 16:42:26

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Properties

Boiling point 560.5±60.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to 65 mg/ml).
form solid
pka 5.13±0.25(Predicted)
color Pale yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII 45II35329V

SAFETY

Risk and Safety Statements

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17764 GKT137831 ≥95% 1218942-37-0 1mg $32 2024-03-01 Buy
Cayman Chemical 17764 GKT137831 ≥95% 1218942-37-0 5mg $74 2024-03-01 Buy
Cayman Chemical 17764 GKT137831 ≥95% 1218942-37-0 10mg $124 2024-03-01 Buy
Cayman Chemical 17764 GKT137831 ≥95% 1218942-37-0 25mg $455 2021-12-16 Buy
TRC C376575 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 1218942-37-0 10mg $220 2021-12-16 Buy
Product number Packaging Price Buy
17764 1mg $32 Buy
17764 5mg $74 Buy
17764 10mg $124 Buy
17764 25mg $455 Buy
C376575 10mg $220 Buy

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Chemical Properties,Uses,Production

Description

GKT-137831 (1218942-37-0) is an NADPH oxidase, NOX1/4 inhibitor (Ki?= 100-150 nM).1? Inhibits erastin-stimulated ROS production.2?Potentiates immunotherapy by overcoming cancer-associated fibroblast- mediated CD8+?T-cell exclusion.3?Reduces ROS production in LPS-stimulated platelets in a mouse model.4?Reduces subarachnoid hemorrhage-induced neuronal death.5?Potent inhibitor of experimental liver fibrosis in mouse models.6

Uses

2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione is a potential drug candidate, which is used in the preparation of pyrazolopyridine derivative as NADPH oxidase inhibitors.

in vivo

During the last half of CCl4 injections, some mice are treated with Setanaxib (GKT137831) daily. CCl4-induced liver fibrosis is more pronounced in SOD1mu compared to WT mice. Liver fibrosis in both SOD1mu and WT mice is attenuated by Setanaxib (GKT137831) treatment. The increased hepatic α-SMA expression is markedly decreased in SOD1mu mice treated with Setanaxib (GKT137831), to a level similar to that of WT mice given the NOX1/4 inhibitor[1].

IC 50

NOX1; NOX4

References

1) Jiang?et al.?(2012),?Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo; Free Radic. Biol. Med.,?53?289 2) Dachert?et al.?(2020),?Targeting ferroptosis in rhabdomyosarcoma cells; Int. J. Cancer,?146(2)?510 3) Ford?et al.?(2020),?NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors; Cancer Res.,?80?1846 4) Naime?et al.?(2019),?Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide; Platelets,?30?1047 5) Zhang?et al.?(2017),?Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage; Free Radic. Res.,?51?316 6) Aoyama?et al.?(2012),?Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent;?Hepatology,?56?2316

2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 150)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 32299 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Chemia Biotechnology(Shanghai) Co., Ltd
+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Labnetwork lnc.
+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38671 58

View Lastest Price from 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Setanaxib pictures 2025-06-19 Setanaxib
1218942-37-0
US $34.00-97.00 / mg 96.72% 10g TargetMol Chemicals Inc.
  • Setanaxib pictures
  • Setanaxib
    1218942-37-0
  • US $34.00-97.00 / mg
  • 96.72%
  • TargetMol Chemicals Inc.
2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione GKT137831 2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-5H-pyrazolo[4,3-c]pyridine-3,6-dione 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione GKT137831 GKT137831, >=98% 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)- CS-1795 GKT-137831;GKT 137831 Setanaxib GKT137831 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione GSK-137831 Setanaxib 1H-Pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione, 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl- GKT-831 GKT137831(Setanaxib) 2- ( 2 - chlorophenyl ) -4- ( 3- ( dimethylamino ) phenyl ) -5 - methyl - 1,2 - dihydro - 3H - pyrazolo [ 4 , Setanaxib, 10 mM in DMSO 1218942-37-0 Inhibitors API