Rilmenidine-d4
- CAS No.
- 85047-14-9
- Chemical Name:
- Rilmenidine-d4
- Synonyms
- Rilmenidine-d4;4,4,5,5-tetradeuterio-N-(dicyclopropylmethyl)-1,3-oxazol-2-amine;Rilmenidine D4Q: What is Rilmenidine D4 Q: What is the CAS Number of Rilmenidine D4 Q: What is the storage condition of Rilmenidine D4 Q: What are the applications of Rilmenidine D4
- CBNumber:
- CB62592381
- Molecular Formula:
- C10H12D4N2O
- Molecular Weight:
- 184.271487112
- MDL Number:
- MOL File:
- 85047-14-9.mol
- MSDS File:
- SDS
Rilmenidine-d4 Chemical Properties,Uses,Production
Biological Activity
Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine by GC- or LC-MS. Rilmenidine is an antihypertensive agent.1 It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.2 Rilmenidine (1 μM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.3 Formulations containing rilmenidine have been used in the treatment of hypertension.
References
1.Gomez, R.E., Ernsbarger, P., Feinland, G., et al.Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 areaEur. J. Pharmacol.195(2)181-191(1991) 2.Burke, S.L., Evans, R.G., and Head, G.A.Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertensionJ. Hypertens.29(5)945-952(2011) 3.Williams, A., Sarkar, S., Cuddon, P., et al.Novel targets for Huntington's disease in an mTOR-independent autophagy pathwayNat. Chem. Biol.4(5)295-305(2008)
Rilmenidine-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Rilmenidine-d4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30237 | 58 |
| Shanghai Champ Biopharmaceuticals Co., Ltd. | 021-61537865 13585780846 | sales@champchem.com | China | 360 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-037163312495,13303845143 13303845143 | 3001379618@qq.com | China | 10376 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4271 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| Shengbaolai Biotechnology Co., Ltd | 86-027-59105235 15527244834 | shengblai@126.com | China | 495 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12582 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | rose.shi@synzest.com | China | 6210 | 58 |