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ChemicalBook >> CAS DataBase List >>1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)-

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)-

CAS No.
2773408-33-4
Chemical Name:
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)-
Synonyms
Antimalarial agent 16;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)-
CBNumber:
CB612763287
Molecular Formula:
C30H32N2O6
Molecular Weight:
516.58
MDL Number:
MOL File:
2773408-33-4.mol
Last updated:2025-04-28 21:36:36

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- Properties

Boiling point 748.5±60.0 °C(Predicted)
Density 1.271±0.06 g/cm3(Predicted)
pka 16.63±0.40(Predicted)

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- Chemical Properties,Uses,Production

Uses

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].

in vivo

Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1].

Animal Model:Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1]
Dosage:40 or 200 mg/kg
Administration:Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days
Result:Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8.
Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.

References

[1] Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:11683 DOI:10.1016/j.bmc.2022.116830

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58

View Lastest Price from 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Antimalarial agent 16 pictures 2025-04-27 Antimalarial agent 16
2773408-33-4
 US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-[(2R)-2-[(4-butyl-7-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]-1-oxopropyl]-2,3,4,9-tetrahydro-, methyl ester, (3S)- Antimalarial agent 16 2773408-33-4