D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID
- CAS No.
- 4350-07-6
- Chemical Name:
- D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID
- Synonyms
- (R)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;D-5-HTP;D-5-HYDROXYTRYPTOPHAN;5-hydroxy-d-tryptopha;Tryptophan Impurity 42;D-Tryptophan, 5-hydroxy-;D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;(2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;(2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propionic acid;(2R)-2-azanyl-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
- CBNumber:
- CB5315752
- Molecular Formula:
- C11H12N2O3
- Molecular Weight:
- 220.22
- MDL Number:
- MFCD00069709
- MOL File:
- 4350-07-6.mol
| Melting point | 270C |
|---|---|
| Boiling point | 520.6±50.0 °C(Predicted) |
| Density | 1.484±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| pka | 2.22±0.10(Predicted) |
| FDA UNII | 0ZQ5SQ239Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H312 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21-20/21/22-36/37/38-65 |
| Safety Statements | 26-36 |
D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS102106 | 5-Hydroxy-D-tryptophan 95% ee | 4350-07-6 | 1g | $634 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0002076 | D-TRYPTOPHAN, 5-HYDROXY- 95.00% | 4350-07-6 | 100MG | $696.36 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0002076 | D-TRYPTOPHAN, 5-HYDROXY- 95.00% | 4350-07-6 | 250MG | $2042.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0002076 | D-TRYPTOPHAN, 5-HYDROXY- 95.00% | 4350-07-6 | 1G | $3825.15 | 2021-12-16 | Buy |
| Crysdot | CD21007194 | (R)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoicacid 95+% | 4350-07-6 | 250mg | $303 | 2021-12-16 | Buy |
D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Chemical Properties,Uses,Production
Uses
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].
Definition
ChEBI: The D-enantiomer of 5-hydroxytryptophan.
in vivo
D-5-Hydroxytryptophan (100, 320 mg/kg; ip; single dose) cannot induce backward walking behavior in mice, while L-5-Hydroxytryptophan can do it[3].
References
[1] J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22. DOI:10.1016/0006-2952(67)90088-3
[2] Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):129-32. PMID:3132733
[3] Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31(1):39-46. DOI:10.1254/jjp.31.39
D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
D-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | thtang@dycnchem.com | China | 53900 | 58 |
| DONBOO AMINO ACID COMPANY | +8618051385538 | donboo@donboo.com | China | 9363 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9887 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 18626450290 | yftan@aikonchem.com | China | 16684 | 50 |
| Shanghai Yihe Biological Technology Co., Ltd. | 17721395025 | 2423903095@qq.com | China | 4381 | 58 |
| Jiaxing Zhejia Biotechnology Co., LTD | 0573-85609002 | zhejia01@163.com | China | 8885 | 58 |
| Hubei Rhema Reference Materials Technology Co., Ltd. | 0712-8899838 15787879035 | ydw9035@rmastandards.com | China | 4608 | 58 |
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