Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI)
![Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI) Structure](CAS/GIF/809272-64-8.gif)
- CAS No.
- 809272-64-8
- Chemical Name:
- Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI)
- Synonyms
- PTP1B-IN-3;PTP1BIN3,PTP-1B-IN-3,PTP1B IN 3;(3-bromo-7-cyanonaphthalen-2-yl)difluoromethylphosphonic acid;P-[(3-BroMo-7-cyano-2-naphthalenyl)difluoroMethyl]phosphonic Acid;Phosphonic acid, P-[(3-bromo-7-cyano-2-naphthalenyl)difluoromethyl]-;Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI);P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonic Acid Diammonium Salt
- CBNumber:
- CB52628263
- Molecular Formula:
- C12H7BrF2NO3P
- Molecular Weight:
- 362.0634474
- MDL Number:
- MFCD19443182
- MOL File:
- 809272-64-8.mol
- MSDS File:
- SDS
| Melting point | >277°C (dec.) |
|---|---|
| Boiling point | 565.7±60.0 °C(Predicted) |
| Density | 1.86±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Very Slightly, Heated), Water (Slightly) |
| pka | 1.35±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| Stability | Hygroscopic |
Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B682735 | P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonicAcidDiammoniumSalt | 809272-64-8 | 1mg | $230 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0316423 | [(3-BROMO-7-CYANO-2-NAPHTHALENYL)DIFLUOROMETHYL]PHOSPHONIC ACID 95.00% | 809272-64-8 | 5MG | $497.34 | 2021-12-16 | Buy |
| ChemScene | CS-0003783 | PTP1B-IN-3 | 809272-64-8 | 1mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0003783 | PTP1B-IN-3 | 809272-64-8 | 5mg | $2500 | 2021-12-16 | Buy |
| ChemScene | CS-0003783 | PTP1B-IN-3 | 809272-64-8 | 10mg | $4400 | 2021-12-16 | Buy |
Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI) Chemical Properties,Uses,Production
Uses
P-[(3-Bromo-7-cyano-2-naphthalenyl)difluoromethyl]phosphonic Acid is a potent and orally active small molecule PTP1B inhibitor.
Definition
ChEBI: [(3-bromo-7-cyano-2-naphthalenyl)-difluoromethyl]phosphonic acid is a member of naphthalenes.
in vivo
In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits dose dependent inhibition (60%, 80% and 100% inhibition at 1, 3 and 10 mg/kg, respectively) of glucose excursion when given orally 2 h before oral glucose challenge with an estimated ED50 of 0.8 mg/kg[1].
In the NDL2 Ptpn1 transgenic mice, PTP1B-IN-3 (compounds 3g; orally; 30 mg/kg for 21 days) shows a significant delay in the onset of tumor development in NDL2 Ptpn1+/+ mice, extending the median tumor free days (T50) from 28 days to 75 days[1].
In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and good elimination half live (t1/2 of 6 h). The oral bioavailability in higher species such as rats (F of 4%) and squirrel monkeys (F of 2%) are substantially lower but excellent exposures are achieved with oral dosing[1].
Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Phosphonic acid, [(3-broMo-7-cyano-2-naphthalenyl)difluoroMethyl]- (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jk.info@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24866 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 55710 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 18215 | 58 |
| Santa Cruz Biotechnology Inc | 60936350 | scbt@scbt.com | China | 222068 | 58 |