FPL 62064
- CAS No.
- 103141-09-9
- Chemical Name:
- FPL 62064
- Synonyms
- FPL 62064;FPL 62064, 10 mM in DMSO;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
- CBNumber:
- CB51384847
- Molecular Formula:
- C16H15N3O
- Molecular Weight:
- 265.31
- MDL Number:
- MFCD00877802
- MOL File:
- 103141-09-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P501-P202-P201-P280-P308+P313-P405 |
FPL 62064 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M350460 | N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine | 103141-09-9 | 100mg | $240 | 2021-12-16 | Buy |
| TRC | M350460 | N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine | 103141-09-9 | 10mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-0024722 | FPL62064 98.46% | 103141-09-9 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0024722 | FPL62064 98.46% | 103141-09-9 | 10mg | $550 | 2021-12-16 | Buy |
| AK Scientific | 3655AL | N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine | 103141-09-9 | 100mg | $298 | 2021-12-16 | Buy |
FPL 62064 Chemical Properties,Uses,Production
Uses
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].
in vivo
FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].
| Animal Model: | Female LACA mice (20-30 g) injected with immune complex[1]. |
| Dosage: | 5 mg/kg, 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation. |
References
[1] Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DOI:10.1007/BF01966309
[2] Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. DOI:10.1002/ardp.201900308
FPL 62064 Preparation Products And Raw materials
Raw materials
Preparation Products
FPL 62064 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32285 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38668 | 58 | |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Hotechem Shanghai Co., Ltd., | 021-34621078 13120882795 | 465106944@qq.com | China | 857 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6448 | 55 |
