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ChemicalBook >> CAS DataBase List >>FPL 62064

FPL 62064

CAS No.
103141-09-9
Chemical Name:
FPL 62064
Synonyms
FPL 62064;FPL 62064, 10 mM in DMSO;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
CBNumber:
CB51384847
Molecular Formula:
C16H15N3O
Molecular Weight:
265.31
MDL Number:
MFCD00877802
MOL File:
103141-09-9.mol
Last updated:2025-04-18 09:52:25

FPL 62064 Properties

Boiling point 442.6±25.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO: 250 mg/mL (942.29 mM)
pka 2.42±0.50(Predicted)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H341
Precautionary statements  P501-P202-P201-P280-P308+P313-P405

FPL 62064 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M350460 N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine 103141-09-9 100mg $240 2021-12-16 Buy
TRC M350460 N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine 103141-09-9 10mg $45 2021-12-16 Buy
ChemScene CS-0024722 FPL62064 98.46% 103141-09-9 5mg $350 2021-12-16 Buy
ChemScene CS-0024722 FPL62064 98.46% 103141-09-9 10mg $550 2021-12-16 Buy
AK Scientific 3655AL N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine 103141-09-9 100mg $298 2021-12-16 Buy
Product number Packaging Price Buy
M350460 100mg $240 Buy
M350460 10mg $45 Buy
CS-0024722 5mg $350 Buy
CS-0024722 10mg $550 Buy
3655AL 100mg $298 Buy

FPL 62064 Chemical Properties,Uses,Production

Uses

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].

in vivo

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].

Animal Model:Female LACA mice (20-30 g) injected with immune complex[1].
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection
Result:Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation.

References

[1] Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DOI:10.1007/BF01966309
[2] Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. DOI:10.1002/ardp.201900308

FPL 62064 Preparation Products And Raw materials

Raw materials

Preparation Products

FPL 62064 Suppliers

Global( 42)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 32285 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38668 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58
Hotechem Shanghai Co., Ltd., 021-34621078 13120882795 465106944@qq.com China 857 56
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6448 55

View Lastest Price from FPL 62064 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FPL 62064 pictures 2024-11-19 FPL 62064
103141-09-9
US $34.00-118.00 / mg 98.79% 10g TargetMol Chemicals Inc.
  • FPL 62064 pictures
  • FPL 62064
    103141-09-9
  • US $34.00-118.00 / mg
  • 98.79%
  • TargetMol Chemicals Inc.

103141-09-9(FPL 62064)Related Search:

1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl- FPL 62064 N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2 FPL 62064, 10 mM in DMSO 103141-09-9