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ChemicalBook >> CAS DataBase List >>4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-

4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-

CAS No.
2636771-29-2
Chemical Name:
4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-
Synonyms
PKC-IN-4;4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-
CBNumber:
CB512617406
Molecular Formula:
C21H25N5S
Molecular Weight:
379.52
MDL Number:
MOL File:
2636771-29-2.mol
Last updated:2025-04-18 09:52:23

4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- Properties

Density 1.257±0.06 g/cm3(Predicted)
pka 10.13±0.29(Predicted)

4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- Chemical Properties,Uses,Production

Uses

PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 μM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1].

in vivo

PKC-IN-4 (10 mg/kg for i.v.; 20 mg/kg for p.o.) shows orally active with oral bioavailability of 81.7%[1].

Animal Model:Animal Model: CD-1 mice[1]
Dosage:10, 20 mg/kg
Administration:10 mg/kg for i.v.; 20 mg/kg for p.o.
Result:Showed good PK parameters with oral bioavailability of 81.7%.

IC 50

PKC: 0.52 μM (IC50)

References

[1] Liu X, et al. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema. Bioorg Med Chem. 2020 Jun 1;28(11):115480. DOI:10.1016/j.bmc.2020.115480

4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21549 58

View Lastest Price from 4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PKC-IN-4 pictures 2025-05-02 PKC-IN-4
2636771-29-2
 US $2785.00-2140.00 / mg 10g TargetMol Chemicals Inc.
  • PKC-IN-4 pictures
  • PKC-IN-4
    2636771-29-2
  • US $2785.00-2140.00 / mg
  • TargetMol Chemicals Inc.
4-Piperidinemethanamine, 1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]- PKC-IN-4 2636771-29-2