FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT
- CAS No.
- Chemical Name:
- FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT
- Synonyms
- FIBRONECTIN PROTEOLYTIC 70 KDA FRAGMENT;FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT;FIBRONECTIN PROTEOLYTIC 30 KDA FRAGMENT;Fibronectin Proteolytic Fragment from human plasma
- CBNumber:
- CB4775582
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00283227
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi,B |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT Chemical Properties,Uses,Production
Uses
Fibronectin proteolytic fragment has been used in solid phase binding assay.
Biological Activity
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.', 'Fibronectins are high molecular weight glycoproteins with two subunits joined by a disulfide bond to form the dimer. The fragments are obtained using protelytic enzymes. This 45 kDa gelatin binding fragment is obtained through trypitc digestion of the N-terminal 70 kDa fragment, which is produced by Cathespin D digestion.
This fragment has an acidic pI (4.9-5.3) and does not bind to heparin. This domain is resistant to proteolysis due to intrachain disulfide bonding and the attached carbohydrate. The intrachain disulfide bonds are essential for binding to gelatin, while the complex, branched, asparagine-linked carbohydrate is not. This fragment binds to C1q, but not to fibrin.
FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT Preparation Products And Raw materials
Raw materials
Preparation Products
FIBRONECTIN PROTEOLYTIC 45 KDA FRAGMENT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck KGaA | (+86) 21 2033 8288 | sigmaname@qq.com | CHINA | 292394 | 58 |
| Supplier | Advantage |
|---|---|
| Merck KGaA | 58 |