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tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
![tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Structure](CAS/GIF/133264-58-1.gif)
- CAS No.
- 133264-58-1
- Chemical Name:
- tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
- Synonyms
- Chloroacetamido-C4-NHBoc;tert-Butyl (4-(2-chloroacetamido)butyl)carbamate;tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate;Carbamic acid, N-[4-[(2-chloroacetyl)amino]butyl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB43328789
- Molecular Formula:
- C11H21ClN2O3
- Molecular Weight:
- 264.75
- MDL Number:
- MFCD24452363
- MOL File:
- 133264-58-1.mol
Last updated:2023-05-15 08:29:04
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 178836 | tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate | 133264-58-1 | 500mg | $516 | 2021-12-16 | Buy |
| Matrix Scientific | 178836 | tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate | 133264-58-1 | 1g | $697 | 2021-12-16 | Buy |
| Matrix Scientific | 178836 | tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate | 133264-58-1 | 5g | $1991 | 2021-12-16 | Buy |
| A2B | AI79696 | tert-butylN-[4-(2-chloroacetamido)butyl]carbamate >95% | 133264-58-1 | 1mg | $152 | 2021-12-16 | Buy |
| A2B | AI79696 | tert-butylN-[4-(2-chloroacetamido)butyl]carbamate >95% | 133264-58-1 | 5mg | $163 | 2021-12-16 | Buy |
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Chemical Properties,Uses,Production
Biological Activity
Chloroacetamido-C4-NHBoc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Synthesis of tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate from tert-Butyl N-(4-aminobutyl)carbamate and Chloroacetyl chloride
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Preparation Products And Raw materials
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Suppliers
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tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
Chloroacetamido-C4-NHBoc
Carbamic acid, N-[4-[(2-chloroacetyl)amino]butyl]-, 1,1-dimethylethyl ester
tert-Butyl (4-(2-chloroacetamido)butyl)carbamate
133264-58-1