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ChemicalBook >> CAS DataBase List >>GN25

GN25

CAS No.
1227401-27-5
Chemical Name:
GN25
Synonyms
GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
CBNumber:
CB42591113
Molecular Formula:
C15H14O6S
Molecular Weight:
322.33
MDL Number:
MOL File:
1227401-27-5.mol
Last updated:2023-05-21 10:59:17

GN25 Properties

Boiling point 608.4±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
form crystalline solid
pka 4.24±0.10(Predicted)

GN25 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10948 GN25 ≥98% 1227401-27-5 5mg $34 2024-03-01 Buy
Cayman Chemical 10948 GN25 ≥98% 1227401-27-5 10mg $64 2024-03-01 Buy
Cayman Chemical 10948 GN25 ≥98% 1227401-27-5 25mg $150 2024-03-01 Buy
Cayman Chemical 10948 GN25 ≥98% 1227401-27-5 50mg $264 2024-03-01 Buy
ApexBio Technology C4840 GN25 1227401-27-5 50mg $299 2021-12-16 Buy
Product number Packaging Price Buy
10948 5mg $34 Buy
10948 10mg $64 Buy
10948 25mg $150 Buy
10948 50mg $264 Buy
C4840 50mg $299 Buy

GN25 Chemical Properties,Uses,Production

Description

The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

References

[1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87.

GN25 Preparation Products And Raw materials

Raw materials

Preparation Products

GN25 Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 25002 58
Shanghai Taopu Industrial Co., LTD 159-00573766 18018507602 394643792@qq.com China 4227 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9266 58
Cayman Chemical Company 800-3649897 Caymanname@qq.com China 21645 58
ApexBio Technology -- sales@apexbt.com United States 6251 58
GN25 DIIRLGMLDOPLPV-UHFFFAOYSA-N Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]- 1227401-27-5