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ChemicalBook >> CAS DataBase List >>2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-

2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-

CAS No.
1332390-06-3
Chemical Name:
2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-
Synonyms
JNJ-pan-AR;2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-
CBNumber:
CB39931780
Molecular Formula:
C25H24F3N5O2S
Molecular Weight:
515.55
MDL Number:
MOL File:
1332390-06-3.mol
Last updated:2025-04-29 09:03:59

2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- Properties

Boiling point 657.0±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
pka 8.16±0.10(Predicted)

2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- Chemical Properties,Uses,Production

Description

JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.

2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58

View Lastest Price from 2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNJ-pan-AR pictures 2025-04-29 JNJ-pan-AR
1332390-06-3
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • JNJ-pan-AR pictures
  • JNJ-pan-AR
    1332390-06-3
  • US $1520.00-1980.00 / mg
  • TargetMol Chemicals Inc.
2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)- JNJ-pan-AR 1332390-06-3