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ChemicalBook >> CAS DataBase List >>Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)-

Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)-

CAS No.
1627729-62-7
Chemical Name:
Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)-
Synonyms
MLK-IN-1;N-(3,4-Dimethoxyphenyl)-3-(7-methoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine;Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)-
CBNumber:
CB38961597
Molecular Formula:
C23H20N4O3S
Molecular Weight:
432.49
MDL Number:
MOL File:
1627729-62-7.mol
Last updated:2025-04-17 18:22:24

Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- Properties

Density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 4.34±0.30(Predicted)
form Solid
color Light yellow to green yellow

Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- Chemical Properties,Uses,Production

Uses

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1[1].

Biological Activity

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1[1]. MLK-IN-1 (100 nM; pre-treatment 20 mins HIV-1 Tat) promotes continued axonogenesis in the presence of Tat-activated microglia and protects against effects of HIV-Tat in vitro[1].

References

[1]. Val S. Goodfellow,et al.Mixed lineage kinase inhibitors and method of treatments. Patent US20140256733A1.

Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232 1282296214@qq.com China 498 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9349 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24893 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Imidazo[1,2-b]pyridazin-6-amine, N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thien-2-yl)- MLK-IN-1 N-(3,4-Dimethoxyphenyl)-3-(7-methoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine 1627729-62-7