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ChemicalBook >> CAS DataBase List >>Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

CAS No.
1111636-35-1
Chemical Name:
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
Synonyms
CS-727;PF-04880594;PF-04880594/PF04880594;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED
CBNumber:
CB32667567
Molecular Formula:
C19H16F2N8
Molecular Weight:
394.38
MDL Number:
MOL File:
1111636-35-1.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Properties

Density 1.48±0.1 g/cm3(Predicted)
storage temp. room temp
solubility Soluble in DMSO
pka 12.99±0.40(Predicted)
form powder
color white to beige
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P304+P340+P312-P305+P351+P338-P337+P313

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0294 PF-04880594 ≥98% (HPLC) 1111636-35-1 5MG $115 2023-06-20 Buy
Sigma-Aldrich PZ0294 PF-04880594 ≥98% (HPLC) 1111636-35-1 25MG $361 2023-06-20 Buy
Medical Isotopes, Inc. 57031 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile 1111636-35-1 5mg $775 2021-12-16 Buy
Medical Isotopes, Inc. 57031 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile 1111636-35-1 50mg $3200 2021-12-16 Buy
DC Chemicals DC8727 PF-04880594 >98% 1111636-35-1 250mg $800 2021-12-16 Buy
Product number Packaging Price Buy
PZ0294 5MG $115 Buy
PZ0294 25MG $361 Buy
57031 5mg $775 Buy
57031 50mg $3200 Buy
DC8727 250mg $800 Buy

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Chemical Properties,Uses,Production

Uses

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors.

Biochem/physiol Actions

PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.

in vivo

PF-04880594 (10 mg/kg) induces ERK phosphorylation and BRAF-CRAF dimerization in multiple epithelial tissues in mice and the induction can be attenuated by PD0325901[1].
PF-04880594 (0-40 mg/kg, twice daily for 3 weeks) induces epithelial hyperplasia in mice and the induction is prevented by PD0325901[1].

Animal Model:Nude mice[1]
Dosage:10 mg/kg alone or in combination with 0.5 mg/kg PD-0325901
Administration:An am and pm dose on day 1 and then an am dose on day 2 approximately 2 hours before the animals were necropsied and the tissues harvested
Result:Induced ERK phosphorylation in urinary bladder, tongue, skin, and esophagus tissues. The induction of ERK phosphorylation was attenuated by cotreatment with 0.5 mg/kg PD0325901.
Animal Model:Nude mice (6–8 weeks old)[1]
Dosage:10, 20 and 40 mg/kg alone or in combination with 0.1, 0.3, 0.5, 1.0, or 2.5 mg/kg PD-0325901
Administration:Twice daily for 3 weeks
Result:Tissues treated with the RAF inhibitor alone display the microscopic pathology typical of unopposed BRAF inhibition. Hyperplasia in nonglandular stomach epithelium was blocked by PD-0325901.

target

BRAFV599E

IC 50

Braf; CRAF

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
J & K SCIENTIFIC LTD. 18210857532 jkinfo@jkchemical.com China 96815 76
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2990 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Jinan elephant international trading co., LTD 13006575422@163.com China 6355 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57422 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613 sales@chemrenpharm.com China 3640 58
Cckinase, Inc. +1 (732)236-3202 sales@cckinase.com United States 2738 58

View Lastest Price from Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-04880594 pictures 2024-11-19 PF-04880594
1111636-35-1
 US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • PF-04880594 pictures
  • PF-04880594
    1111636-35-1
  • US $2500.00-1980.00 / mg
  • TargetMol Chemicals Inc.
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- PF-04880594 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile PF-04880594/PF04880594 CS-727 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED 1111636-35-1 C19H16F2N8