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ChemicalBook >> CAS DataBase List >>Lumacaftor (VX-809)

Lumacaftor (VX-809)

CAS No.
936727-05-8
Chemical Name:
Lumacaftor (VX-809)
Synonyms
Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;Rumakato;VRT 826809;3-(6-{[1-(2;VX809;VX-809
CBNumber:
CB32489655
Molecular Formula:
C24H18F2N2O5
Molecular Weight:
452.41
MDL Number:
MFCD16659051
MOL File:
936727-05-8.mol
MSDS File:
SDS
Last updated:2025-04-30 08:50:00

Lumacaftor (VX-809) Properties

Melting point 200-205oC
Boiling point 653.0±55.0 °C(Predicted)
Density 1.51
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka 3.95±0.10(Predicted)
form Solid
color White to Off-White
InChIKey UFSKUSARDNFIRC-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C5OC(F)(F)OC5=C4)CC3)=O)=CC=C2C)=C1
FDA UNII EGP8L81APK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
3 0

Lumacaftor (VX-809) price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22196 VX-809 ≥98% 936727-05-8 1mg $37 2024-03-01 Buy
Cayman Chemical 22196 VX-809 ≥98% 936727-05-8 5mg $151 2024-03-01 Buy
Cayman Chemical 22196 VX-809 ≥98% 936727-05-8 10mg $266 2024-03-01 Buy
Cayman Chemical 22196 VX-809 ≥98% 936727-05-8 25mg $573 2024-03-01 Buy
Usbiological 273822 VX-809 936727-05-8 50mg $389 2021-12-16 Buy
Product number Packaging Price Buy
22196 1mg $37 Buy
22196 5mg $151 Buy
22196 10mg $266 Buy
22196 25mg $573 Buy
273822 50mg $389 Buy

Lumacaftor (VX-809) Chemical Properties,Uses,Production

Uses

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.

Biological Activity

vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several

target

CFTR

Mode of action

CF is a hereditary condition caused by mutations in the CFTR gene, which provides instructions for producing an ion channel protein called CF transmembrane conductance regulator (CFTR). These mutations cause defects in the CFTR protein, which disrupts the normal salt-water transport across the cell membrane and produces thick, sticky mucus that may accumulate in different organs, including the lungs. One of the common mutations in the CFTR gene is the so-called F508del mutation, which results in a defective misfolded CFTR protein. The misfolded protein is degraded by the cell before it can reach the cell membrane. Even if some of the defective proteins reach the cell membrane, they are unable to open correctly and allow the passage of chloride ions. Lumacaftor and ivacaftor work together to restore the function of the CFTR protein at the cell membrane. Lumacaftor increases the stability of defective CFTR proteins, helping them reach the cell membrane and stay there longer. But because it does not address the problem with the opening of the channel, lumacaftor is generally used in combination with ivacaftor, which acts on the defective proteins, helping them to open more often so that the salt-water balance across the cell surface is restored.

Lumacaftor (VX-809) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 247)Suppliers
Supplier Tel Email Country ProdList Advantage
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
+86-0311-67591193 +8613931880626 sales02@dingminpharma.com China 256 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15531157085; +8615531157085 abby@chuanghaibio.com China 8807 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12790 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 2998 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20231 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368 sales@sjar-tech.com China 485 58
Moxin Chemicals 		+8617320513646 Anna@molcoo.com China 10186 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55

View Lastest Price from Lumacaftor (VX-809) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lumacaftor Impurity pictures 2025-05-09 Lumacaftor Impurity
936727-05-8
 US $0.00-0.00 / mg 10mg 98 10000000 Moxin Chemicals
Lumacaftor (VX-809) pictures 2025-05-09 Lumacaftor (VX-809)
936727-05-8
 US $0.00 / g/Bag 1g 98.0%~102.0% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Lumacaftor pictures 2025-04-30 Lumacaftor
936727-05-8
 US $43.00-75.00 / mg 99.72% 10g TargetMol Chemicals Inc.
  • Lumacaftor pictures
  • Lumacaftor
    936727-05-8
  • US $43.00-75.00 / mg
  • 99.72%
  • TargetMol Chemicals Inc.

Lumacaftor (VX-809) Spectrum

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid VRT 826809 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be VX 809, >=98% VX-809 (LUMACAFTOR);VX 809 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl VX-809 + IVACAFTOR VX-809 (LuMacaftor) 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor VX809;VX-809 3-(6-{[1-(2 Lumacaftor VX809 VX-809, Lumacaftor, VRT 826809 3-{6-[1-(2,2-difluoro-1,3-dioxaindan-5-yl)cycloprop aneamido]-3-methylpyridin-2-yl}benzoic acid 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropaneca... Benzoic acid, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]- CS-719 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid VX-809 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid Lumacaftor Lumacaftor(vx-809,vx809) 3-(6-(1-(2,2-Difluorobenzod1,3dioxol-5-yl)cyclopropane-carboxcarboxamido)-3-methylpyridin-2-yl)-benzoic acid Lumacaftor in methanol Rumakato Lumacaftor, 10 mM in DMSO 936727-05-8 Inhibitors VX-809