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ChemicalBook >> CAS DataBase List >>Febantel

Febantel

CAS No.
58306-30-2
Chemical Name:
Febantel
Synonyms
rintal;Febantel;Febante1;bayvh5757;Bay h-5757;FEBANTEL EP;Non Bantyre;Febantel CRS;Febantel EP/BP;Febantel powder
CBNumber:
CB2502427
Molecular Formula:
C20H22N4O6S
Molecular Weight:
446.48
MDL Number:
MFCD01738527
MOL File:
58306-30-2.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

Febantel Properties

Melting point 129-130°C
Boiling point 215°C (rough estimate)
Density 1.2962 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Sparingly)
form Solid
pka 7.60±0.46(Predicted)
color White to Off-White
Merck 14,3944
InChI InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)
InChIKey HMCCXLBXIJMERM-UHFFFAOYSA-N
SMILES N(C1C=C(SC2C=CC=CC=2)C=CC=1/N=C(\NC(=O)OC)/NC(=O)OC)C(=O)COC
CAS DataBase Reference 58306-30-2(CAS DataBase Reference)
FDA UNII S75C401OS1
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  FB3955000
HS Code  2930902000

Febantel price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33981 Febantel VETRANAL?, analytical standard 58306-30-2 100mg $108 2024-03-01 Buy
Sigma-Aldrich 1269356 Febantel United States Pharmacopeia (USP) Reference Standard 58306-30-2 200mg $467 2024-03-01 Buy
TCI Chemical F0922 Febantel 58306-30-2 1g $40 2024-03-01 Buy
TCI Chemical F0922 Febantel 58306-30-2 5g $190 2024-03-01 Buy
Sigma-Aldrich Y0000660 Febantel for system suitability European Pharmacopoeia (EP) Reference Standard 58306-30-2 y0000660 $157 2024-03-01 Buy
Product number Packaging Price Buy
33981 100mg $108 Buy
1269356 200mg $467 Buy
F0922 1g $40 Buy
F0922 5g $190 Buy
Y0000660 y0000660 $157 Buy

Febantel Chemical Properties,Uses,Production

Description

Febantel [N-2-( [2,3-bis-(methoxycarbonyl)-guanidine] 5- phenylthio)-phenyl) -2-methoxyacetamide] is a new anthelmintic that is highly active against various species of nematodes and cestodes in rodents, sheep, cattle, and horses. In 1978, febantel was introduced to South Africa under the trade name of Rintal? as a sheep drench, and to New Zealand as a sheep and cattle drench, and the USA and Australia as a paste for horse[1].

Chemical Properties

Febantel is White to Off-White Solid

Originator

Rintal, Bayer,W. Germany,1979

Uses

Used as an anthelmintic.

Definition

ChEBI: Febantel is an aryl sulfide.

Manufacturing Process

2-Amino-5-phenylthiornethoxyacetanilide in methanol solution is heated with N,N'-bis-methoxycarbonyl-isothiourea-S-methyl ether with the addition of a catalytic amount of p-toluenesulfonic acid for three hours with stirring under reflux. The mixture is then filtered hot and after cooling the febantel product crystallizes out. It is filtered off, rinsed with ether and dried under high vacuum to give the final product, melting at 129°C to 130°C.

brand name

Combotel (Bayer AnimalHealth); Negabot Plus Paste (Bayer Animal Health); Oratel (Bayer Animal Health); Rintal (Bayer Animal Health).

Therapeutic Function

Anthelmintic

in vivo

In vivo assays indicated that febantel exhibited potent anthelmintic activity against G. kobayashii with an EC50 value of 0.03 mg/L and 100 % anthelmintic efficacy at 0.1 mg/L after 48 h of exposure. Moreover, in vivo trials also revealed a notable post-treatment effect of febantel, where infected goldfish transferred to drug-free water after short 6-h exposure could still result in full eradication of the worms, indicating febantel might induce persistent perturbations in parasite physiology[1].

in vivo

In vitro assays showed a negative correlation between febantel concentrations and the survival of G. Kobayashi. However, increasing the febantel concentration to 2.0 mg/L did not result in the complete death of all worms. Oral administration of febantel demonstrated limited anthelmintic activity, with only 49 % efficacy at 200 mg/kg body weight daily over five days. Acute toxicity assays revealed that the 48-h LC50 value of febantel was 5.47 mg/L, 182.23 times higher than the 48-h EC50 value, indicating that febantel has a favorable safety profile. However, febantel exposure potentially interfered with hepatic metabolism and oxidative status, as indicated by variations in SOD, GST, and P450 gene expression[1].

References

[1] Thomas, H. “Ovacidal activity of febantel.” New Zealand veterinary journal 27 12 (1979): 273–5.

Febantel Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 370)Suppliers
Supplier Tel Email Country ProdList Advantage
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988 sales@pipharma.com.cn China 151 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15531157085 +86-15531157085 abby@chuanghaibio.com China 8808 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5870 58
airuikechemical co., ltd. 		+86-18353166132 +86-18353166132 sales02@airuikechemical.com China 983 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-17396673057 linda@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21629 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2986 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29860 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58

View Lastest Price from Febantel manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Febantel pictures 2025-04-16 Febantel
58306-30-2
 US $0.00 / Kg/Drum 1KG 97.5%-101.0%;EP 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Febantel pictures 2025-04-16 Febantel
58306-30-2
 US $0.00 / Kg/Bag 2Kg/Bag EP / Vet GMP 20 tons Sinoway Industrial co., ltd.
Febantel pictures 2025-04-16 Febantel
58306-30-2
 US $25.00 / ASSAYS 100ASSAYS 99.5% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
  • Febantel pictures
  • Febantel
    58306-30-2
  • US $0.00 / Kg/Drum
  • 97.5%-101.0%;EP
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Febantel pictures
  • Febantel
    58306-30-2
  • US $0.00 / Kg/Bag
  • EP / Vet GMP
  • Sinoway Industrial co., ltd.
  • Febantel pictures
  • Febantel
    58306-30-2
  • US $25.00 / ASSAYS
  • 99.5%
  • Hebei Chuanghai Biotechnology Co., Ltd

Febantel Spectrum

FEBANTEL PESTANAL 2-Acetamido-5-nitrothiazole VETRANAL DIMETHYL[[2-[(METHOXYACETYL)AMINO]-4-(PHENYLTHIO)PHENYL]CARBONIMIDOYL]BISCARBAMATE(FEBANTEL) Febantel N-{2-[2,3-Bis-(methoxycarbonyl)-guanido]-5-(phenylthio)-phenyl}-2-methoxyacetamide Carbamicacid,[[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-,dimethylester n-(2-(2,3-bis-(methoxycarbonyl)-guanidino)-5-(phenylthio)-phenyl)-2-methoxya rintal [N-[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic acid dimethyl ester Bay h-5757 N,N'-[[2-[(2-Methoxyacetyl)amino]-4-(phenylthio)phenyl]imidocarbonyl]bis(carbamic acid methyl) ester FEBANTEL EP Thiophenol guanidine febantel pestanal Solution, 100ppm methyl (2-(2-methoxyacetamido)-4-(phenylthio)phenylamino)(methoxycarbonylamino)methylenecarbamate [[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]-carbonimidoyl]biscarbamicaciddimethylester bayvh5757 carbamicacid,((2-((methoxyacetyl)amino)-4-(phenylthio)phenyl)carbonimidoyl)bi Febantel powder (NE)-N-[(methoxycarbonylamino)-[2-[(2-methoxy-1-oxoethyl)amino]-4-(phenylthio)anilino]methylidene]carbamic acid methyl ester Febantel for system suitability CRS Febantel CRS Febantel Standard Pro-benzimidazole methyl N-[N-[2-[(2-methoxyacetyl)amino]-4-phenylsulfanyl-phenyl]-N'-methoxycarbonyl-carbamimidoyl]carbamate 　 Carbamic acid, N,N'-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-, C,C'-dimethyl ester Febantel solution in Acetonitrile, 100μg/mL Febantel USP/EP/BP N-(((2-(2-MEthoxyacetamido)-4-(phenylsulfanyl)phenyl)amino)((methoxycarbonyl)imino)methyl)carbamate Febantel (1269356) 5-Dimethoxyphenol Febantel EP/BP Methyl 3-[[2-(2-Methoxyacetylamino)-4-phenylthiophenyl]amino]-3-(methoxycarbonylamino)-2-aza-2-propenoate Febante1 C13407000 Febantel Febantel Impurity Non Bantyre Febantel, 10 mM in DMSO 58306-30-2 C20H22N4O6S Pharmaceutical intermediate Intermediates & Fine Chemicals Pharmaceuticals 58306-30-2