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ChemicalBook >> CAS DataBase List >>2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

CAS No.
1675201-83-8
Chemical Name:
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
Synonyms
BMS-1;T3655;CS-2413;avelumab/PD-L1;PD-1PD-L1 inhibitor;PD1-PDL1 inhibitor 1;BMS-1, 10 mM in DMSO;PD-1/PD-L1 inhibitor 1(C1);BMS-1 (PD-1/PD-L1 inhibitor 1);PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1)
CBNumber:
CB23049190
Molecular Formula:
C29H33NO5
Molecular Weight:
475.58
MDL Number:
MFCD28978741
MOL File:
1675201-83-8.mol
Last updated:2024-11-19 20:33:22

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Properties

Boiling point 630.2±55.0 °C(Predicted)
Density 1.182±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
pka 2.34±0.20(Predicted)
form solid
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19914 PD-1/PD-L1 Inhibitor 1 ≥98% 1675201-83-8 1mg $36 2024-03-01 Buy
Cayman Chemical 19914 PD-1/PD-L1 Inhibitor 1 ≥98% 1675201-83-8 5mg $112 2024-03-01 Buy
Cayman Chemical 19914 PD-1/PD-L1 Inhibitor 1 ≥98% 1675201-83-8 10mg $207 2024-03-01 Buy
Cayman Chemical 19914 PD-1/PD-L1 Inhibitor 1 ≥98% 1675201-83-8 25mg $384 2024-03-01 Buy
ChemScene CS-5545 BMS-1 99.61% 1675201-83-8 100mg $1056 2021-12-16 Buy
Product number Packaging Price Buy
19914 1mg $36 Buy
19914 5mg $112 Buy
19914 10mg $207 Buy
19914 25mg $384 Buy
CS-5545 100mg $1056 Buy

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Uses,Production

Description

PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1

Uses

BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.

in vitro

pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].

IC 50

0.006-0.10 μm

References

1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 111)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58

View Lastest Price from 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BMS-1 pictures 2024-11-19 BMS-1
1675201-83-8
 US $48.00-112.00 / mg 99.86% 10g TargetMol Chemicals Inc.
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- pictures 2019-12-20 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
1675201-83-8
 US $1.00 / g 1g 99% KG/T Career Henan Chemical Co
  • BMS-1 pictures
  • BMS-1
    1675201-83-8
  • US $48.00-112.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Spectrum

1675201-83-8(2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-)Related Search:

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- PD1-PDL1 inhibitor 1 PD-1PD-L1 inhibitor (2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid avelumab/PD-L1 T3655 (2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1) BMS-1 (PD-1/PD-L1 inhibitor 1) CS-2413 PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1 PD-1/PD-L1 inhibitor 1(C1) BMS-1 (S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid PD-1/PD-L1 inhibitor Impurity 8 (BMS 1) PD-1/PD-L1 inhibitor 1, small molecule inhibitor BMS-1, 10 mM in DMSO 1675201-83-8