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ChemicalBook >> CAS DataBase List >>Ningetinib Tosylate

Ningetinib Tosylate

CAS No.
1394820-77-9
Chemical Name:
Ningetinib Tosylate
Synonyms
CT-053;112176;CT-053 tosylate;Ningetinib (Tosylate);Ningetinib-Tosylate(tosylate);Ningetinib Tosylate, 10 mM in DMSO;Ningetinib Tosylate (CT-053 Tosylate);N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-ph;VEGFR,c-Met/HGFR,Inhibitor,TAM Receptor,Tyro3,inhibit,Axl,Vascular endothelial growth factor receptor,Ningetinib,Ningetinib Tosylate,Mer;N-(3-fluoro-4-((7-(2-hydroxy-2-Methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-diMethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide p-toluenesulfonate
CBNumber:
CB22723675
Molecular Formula:
C38H37FN4O8S
Molecular Weight:
728.7857832
MDL Number:
MFCD28142839
MOL File:
1394820-77-9.mol
Last updated:2025-04-17 18:22:24

Ningetinib Tosylate Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO: 33.33 mg/mL (45.73 mM); Water: < 0.1 mg/mL (insoluble)
form Solid
color White to off-white
FDA UNII R7I5725FES
NCI Drug Dictionary ningetinib tosylate

SAFETY

Risk and Safety Statements

HS Code  2933998090

Ningetinib Tosylate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0027426 NingetinibTosylate 99.92% 1394820-77-9 5mg $100 2021-12-16 Buy
ChemScene CS-0027426 NingetinibTosylate 99.92% 1394820-77-9 10mg $160 2021-12-16 Buy
Apolloscientific BISN0068 NingetinibTosylate 99% 1394820-77-9 5mg $211 2021-12-16 Buy
ChemScene CS-0027426 NingetinibTosylate 99.92% 1394820-77-9 25mg $300 2021-12-16 Buy
Biosynth Carbosynth BN168496 Ningetinib tosylate 1394820-77-9 25mg $425 2021-12-16 Buy
Product number Packaging Price Buy
CS-0027426 5mg $100 Buy
CS-0027426 10mg $160 Buy
BISN0068 5mg $211 Buy
CS-0027426 25mg $300 Buy
BN168496 25mg $425 Buy

Ningetinib Tosylate Chemical Properties,Uses,Production

Uses

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

in vivo

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib Tosylate (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib Tosylate prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group[1].

IC 50

Axl; VEGFR2: 1.9 nM (IC50)

References

[1] Ning Xi, et al. Abstract 1755: CT053PTSA, a novel c-MET and VEGFR2 inhibitor, potently suppresses angiogenesis and tumor growth. Cancer Res 2014;74(19 Suppl):Abstract nr 1755.

Ningetinib Tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

Ningetinib Tosylate Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38669 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10989 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Chemleader Biomedical Co., Limited. 021-58180488 sales@MedChemLeader.com China 1005 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
ChemShuttle, Inc. 0150-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9491 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3475 58

View Lastest Price from Ningetinib Tosylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ningetinib Tosylate pictures 2024-11-19 Ningetinib Tosylate
1394820-77-9
 US $41.00-113.00 / mg 99.93% 10g TargetMol Chemicals Inc.

Ningetinib Tosylate Spectrum

N-(3-fluoro-4-((7-(2-hydroxy-2-Methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-diMethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide p-toluenesulfonate N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-ph 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-, 4- methylbenzenesulfonate (1:1) 112176 CT-053 Ningetinib-Tosylate(tosylate) CT-053 tosylate Ningetinib Tosylate (CT-053 Tosylate) N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 4-methylbenzenesulfonate Ningetinib (Tosylate) VEGFR,c-Met/HGFR,Inhibitor,TAM Receptor,Tyro3,inhibit,Axl,Vascular endothelial growth factor receptor,Ningetinib,Ningetinib Tosylate,Mer Ningetinib Tosylate, 10 mM in DMSO 1394820-77-9 C38H37FN4O8S