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ChemicalBook >> CAS DataBase List >>6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy-

6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy-

CAS No.
2588211-44-1
Chemical Name:
6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy-
Synonyms
Topoisomerase I inhibitor 2;6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy-
CBNumber:
CB212230688
Molecular Formula:
C18H15NO3
Molecular Weight:
293.32
MDL Number:
MOL File:
2588211-44-1.mol
Last updated:2025-04-28 21:36:36

6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- Properties

Boiling point 495.0±45.0 °C(Predicted)
Density 1.261±0.06 g/cm3(Predicted)
pka 3.88±0.20(Predicted)

6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- Chemical Properties,Uses,Production

Uses

Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect[1].

IC 50

Topoisomerase I: 0.58 μM (IC50)

References

[1] Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May. 122:105747. DOI:10.1016/j.bioorg.2022.105747

6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- Preparation Products And Raw materials

Raw materials

Preparation Products

6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com; 18616537568 hanfangpharma@126.com China 29980 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58

View Lastest Price from 6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Topoisomerase I inhibitor 2 pictures 2025-04-28 Topoisomerase I inhibitor 2
2588211-44-1
 US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- Topoisomerase I inhibitor 2 2588211-44-1