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ChemicalBook >> CAS DataBase List >>4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-

CAS No.
917572-74-8
Chemical Name:
4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-
Synonyms
98N12-5;N,N'-didodecyl-4,7,13-tris[2-(dodecylcarbamoyl)ethyl]-4,7,10,13-tetraazahexadecanediamide;N1,N16-Didodecyl-4,7,13-tris(3-(dodecylamino)-3-oxopropyl)-4,7,10,13-tetraazahexadecanediamide;4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-
CBNumber:
CB210814947
Molecular Formula:
C81H163N9O5
Molecular Weight:
1343.22
MDL Number:
MOL File:
917572-74-8.mol
Last updated:2025-04-17 18:22:24

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- Properties

Boiling point 1225.6±65.0 °C(Predicted)
Density 0.942±0.06 g/cm3(Predicted)
solubility Chloroform: 30 mg/ml
form A crystalline solid
pka 15.70±0.46(Predicted)
color Off-white to light yellow

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- Chemical Properties,Uses,Production

Description

98N12-5 is an ionizable cationic lipid.1 It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.2

Uses

98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA-delivery to the liver.

References

1. Akinc, A., Goldberg, M., Qin, J., et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver Mol. Ther. 17(5),872-879(2009).
2. Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc. Natl. Acad. Sci. USA 105(33),11915-11920(2008).

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- Suppliers

Global( 17)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4621 55
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 512 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1987 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24893 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 10000 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6186 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 13854185395; info@easycdmo.com China 10030 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- 98N12-5 N1,N16-Didodecyl-4,7,13-tris(3-(dodecylamino)-3-oxopropyl)-4,7,10,13-tetraazahexadecanediamide N,N'-didodecyl-4,7,13-tris[2-(dodecylcarbamoyl)ethyl]-4,7,10,13-tetraazahexadecanediamide 917572-74-8 C81H163N9O5