Uses
Amoxicillin (Amoxycillin) arginine is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin arginine inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].
in vivo
Amoxicillin (Amoxycillin) arginine (7 mg/kg; i.h.; female ICR/Swiss mice) inhibits strain numbers and improves the survival rate of rats in 1 mg/L or less[2].
Amoxicillin (Amoxycillin) arginine (1.6-9.5 mg/kg; p.o.; daily, for 7 or 14 days; swiss albino mice) has against infection with chlamydia trachomatis in mice[3].
| Animal Model: | Female ICR/Swiss mice[2] |
| Dosage: | 7 mg/kg |
| Administration: | Subcutaneous injection; every 8 h, for 24 hours |
| Result: | Inhibited bacterial numbers in a dose-dependent manner. |
| Animal Model: | Female ICR/Swiss mice[2] |
| Dosage: | 7 mg/kg |
| Administration: | Subcutaneous injection; every 8 h, for 4 days |
| Result: | Survived all animals that were infected with organisms for which MICs were 1 mg/L or less, and with the two strains for which MICs were 2 mg/L, 20 to 40% mortality. |
| Animal Model: | Swiss albino mice[3] |
| Dosage: | 1.6 and 9.5 mg/kg |
| Administration: | Oral administration; daily, for 7 or 14 days |
| Result: | Improved the activity of Chlamydia trachomatis infection in mice. |
References
[1] Guo Y, et, al. Metabolic response of Lactobacillus acidophilus exposed to amoxicillin. J Antibiot (Tokyo). 2022 May;75(5):268-281. DOI:10.1038/s41429-022-00518-6
[2] Andes D, et, al. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrob Agents Chemother. 1998 Sep;42(9):2375-9. DOI:10.1128/AAC.42.9.2375
[3] Kramer MJ, et, al. Activity of oral amoxicillin, ampicillin, and oxytetracycline against infection with chlamydia trachomatis in mice. J Infect Dis. 1979 Jun;139(6):717-9. DOI:10.1093/infdis/139.6.717
![L-arginine [2S-[2alpha,5alpha,6beta(S*)]]-6-[amino(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Structure](CAS/GIF/59261-05-1.gif)